Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 2174177..2174810 | Replicon | chromosome |
| Accession | NZ_CP035680 | ||
| Organism | Vibrio navarrensis strain 08-2462 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMA6 |
| Locus tag | EWA66_RS10485 | Protein ID | WP_000843587.1 |
| Coordinates | 2174177..2174509 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | EWA66_RS10490 | Protein ID | WP_000071008.1 |
| Coordinates | 2174496..2174810 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EWA66_RS10430 | 2169543..2169668 | + | 126 | WP_081946665.1 | DUF3265 domain-containing protein | - |
| EWA66_RS10435 | 2169697..2169993 | + | 297 | WP_039445218.1 | Dabb family protein | - |
| EWA66_RS10440 | 2170156..2170455 | + | 300 | WP_039445221.1 | hypothetical protein | - |
| EWA66_RS10445 | 2170452..2170598 | + | 147 | WP_081947403.1 | DUF3265 domain-containing protein | - |
| EWA66_RS10450 | 2170615..2171445 | + | 831 | WP_039445222.1 | DUF2971 domain-containing protein | - |
| EWA66_RS10455 | 2171442..2171558 | + | 117 | WP_081947405.1 | DUF3265 domain-containing protein | - |
| EWA66_RS10460 | 2171746..2171925 | + | 180 | WP_071169524.1 | DUF645 family protein | - |
| EWA66_RS10465 | 2172123..2172395 | + | 273 | WP_039445224.1 | antibiotic biosynthesis monooxygenase | - |
| EWA66_RS10470 | 2172543..2173319 | + | 777 | WP_039445226.1 | hypothetical protein | - |
| EWA66_RS10475 | 2173334..2173426 | + | 93 | WP_140112951.1 | DUF3265 domain-containing protein | - |
| EWA66_RS10480 | 2173466..2174002 | + | 537 | WP_021448741.1 | GNAT family N-acetyltransferase | - |
| EWA66_RS10485 | 2174177..2174509 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EWA66_RS10490 | 2174496..2174810 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
| EWA66_RS10495 | 2175261..2175380 | + | 120 | Protein_1960 | DUF3265 domain-containing protein | - |
| EWA66_RS10500 | 2175507..2176631 | + | 1125 | WP_154199795.1 | ISAs1 family transposase | - |
| EWA66_RS10505 | 2177018..2177143 | + | 126 | WP_081947386.1 | DUF3265 domain-containing protein | - |
| EWA66_RS10510 | 2177222..2177491 | + | 270 | WP_039444489.1 | hypothetical protein | - |
| EWA66_RS10515 | 2177507..2177617 | + | 111 | Protein_1964 | DUF3265 domain-containing protein | - |
| EWA66_RS10520 | 2178275..2178403 | + | 129 | WP_081946544.1 | DUF3265 domain-containing protein | - |
| EWA66_RS10525 | 2178433..2178906 | + | 474 | WP_039444376.1 | hypothetical protein | - |
| EWA66_RS10530 | 2179360..2179485 | + | 126 | WP_081946665.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1923154..2273696 | 350542 | |
| - | inside | Integron | - | - | 2111244..2195416 | 84172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T118241 WP_000843587.1 NZ_CP035680:2174177-2174509 [Vibrio navarrensis]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T118241 NZ_CP035680:2174177-2174509 [Vibrio navarrensis]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAGTATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAATCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGTAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCCGATTTGAATGCAAATCAAAGAAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAGTATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAATCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGTAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCCGATTTGAATGCAAATCAAAGAAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT118241 WP_000071008.1 NZ_CP035680:2174496-2174810 [Vibrio navarrensis]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT118241 NZ_CP035680:2174496-2174810 [Vibrio navarrensis]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAACAGCATTCGGAAGGTAAGCTTACGCT
GAAAACACATCATGTGAATGACGTGGGAGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTTAATA
TGTCCCGCGGAGTTTTCGCGCGGTTACTTCATACGTCTTCACGCACATTAGAAAACTGGGAACAAGGTCGTAGCGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAACAGCATTCGGAAGGTAAGCTTACGCT
GAAAACACATCATGTGAATGACGTGGGAGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTTAATA
TGTCCCGCGGAGTTTTCGCGCGGTTACTTCATACGTCTTCACGCACATTAGAAAACTGGGAACAAGGTCGTAGCGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|