Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2157350..2157860 Replicon chromosome
Accession NZ_CP035680
Organism Vibrio navarrensis strain 08-2462

Toxin (Protein)


Gene name relB Uniprot ID A0A7Z7VK37
Locus tag EWA66_RS10320 Protein ID WP_000098715.1
Coordinates 2157597..2157860 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7Y3QZ95
Locus tag EWA66_RS10315 Protein ID WP_001223794.1
Coordinates 2157350..2157604 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EWA66_RS10255 2153282..2153407 + 126 WP_081947414.1 DUF3265 domain-containing protein -
EWA66_RS10260 2153437..2154135 + 699 WP_039445765.1 DUF2971 domain-containing protein -
EWA66_RS10265 2154164..2154241 + 78 WP_081947419.1 DUF3265 domain-containing protein -
EWA66_RS10275 2154578..2155231 + 654 WP_052074357.1 hypothetical protein -
EWA66_RS10280 2155424..2155675 + 252 WP_039445767.1 hypothetical protein -
EWA66_RS10285 2155675..2155788 + 114 WP_081947416.1 DUF3265 domain-containing protein -
EWA66_RS10290 2155844..2156317 + 474 WP_052074358.1 hypothetical protein -
EWA66_RS10295 2156335..2156463 + 129 WP_081947417.1 DUF3265 domain-containing protein -
EWA66_RS10305 2156770..2156829 + 60 WP_152593460.1 hypothetical protein -
EWA66_RS10310 2157105..2157260 + 156 WP_081947418.1 DUF3265 domain-containing protein -
EWA66_RS10315 2157350..2157604 + 255 WP_001223794.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EWA66_RS10320 2157597..2157860 + 264 WP_000098715.1 Txe/YoeB family addiction module toxin Toxin
EWA66_RS10330 2158024..2158632 + 609 WP_039439438.1 pyridoxamine 5'-phosphate oxidase family protein -
EWA66_RS10335 2158658..2158750 + 93 WP_195717864.1 DUF3265 domain-containing protein -
EWA66_RS10340 2158936..2159118 + 183 WP_000947519.1 DUF645 family protein -
EWA66_RS10350 2159471..2159653 + 183 WP_046126209.1 DUF645 family protein -
EWA66_RS10355 2160180..2160302 + 123 WP_131070167.1 DUF3265 domain-containing protein -
EWA66_RS10360 2160337..2160585 + 249 WP_039444405.1 hypothetical protein -
EWA66_RS10365 2160730..2161101 + 372 WP_039444419.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1923154..2273696 350542
- inside Integron - - 2111244..2195416 84172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10415.75 Da        Isoelectric Point: 7.9816

>T118240 WP_000098715.1 NZ_CP035680:2157597-2157860 [Vibrio navarrensis]
MSSRLLSWTDESWDDYLYWQTQDKKTLKRINKIINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDNAITI
ISCRYHY

Download         Length: 264 bp

>T118240 NZ_CP035680:2157597-2157860 [Vibrio navarrensis]
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAAGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGATT
ATTTCGTGTCGCTACCATTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.64 Da        Isoelectric Point: 5.0481

>AT118240 WP_001223794.1 NZ_CP035680:2157350-2157604 [Vibrio navarrensis]
MRIVSFTEARNSLKAVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAGKVTQRD
LIDE

Download         Length: 255 bp

>AT118240 NZ_CP035680:2157350-2157604 [Vibrio navarrensis]
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCCGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAACGCTGAACATCTAAACCGTTCCATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7VK37

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3QZ95

References