Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 97423..98014 Replicon chromosome
Accession NZ_CP035503
Organism Rhodoferax sediminis strain CHu59-6-5

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EUB48_RS00515 Protein ID WP_142817040.1
Coordinates 97423..97719 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag EUB48_RS00520 Protein ID WP_210411676.1
Coordinates 97703..98014 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EUB48_RS00485 93805..94314 + 510 WP_168226793.1 pilin -
EUB48_RS00490 94625..95389 + 765 WP_142817035.1 pilus assembly protein -
EUB48_RS00495 95460..95768 + 309 WP_142817036.1 hypothetical protein -
EUB48_RS00500 96001..96255 + 255 WP_142817037.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EUB48_RS00505 96252..96671 + 420 WP_210411729.1 PIN domain-containing protein -
EUB48_RS00510 96774..97313 - 540 WP_142817039.1 GDP-mannose 4,6-dehydratase -
EUB48_RS00515 97423..97719 + 297 WP_142817040.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EUB48_RS00520 97703..98014 + 312 WP_210411676.1 putative addiction module antidote protein Antitoxin
EUB48_RS00525 98059..99078 - 1020 WP_142817042.1 UDP-glucose 4-epimerase GalE -
EUB48_RS00530 99112..99537 - 426 WP_210411677.1 putative toxin-antitoxin system toxin component, PIN family -
EUB48_RS00535 99534..99773 - 240 WP_142817044.1 CopG family transcriptional regulator -
EUB48_RS00540 99838..101364 + 1527 WP_142817045.1 O-antigen ligase C-terminal domain-containing protein -
EUB48_RS00545 101366..101521 - 156 Protein_105 cyclic pyranopterin monophosphate synthase MoaC -
EUB48_RS00550 101801..102184 - 384 WP_142817046.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(7-98)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11193.98 Da        Isoelectric Point: 10.4621

>T118013 WP_142817040.1 NZ_CP035503:97423-97719 [Rhodoferax sediminis]
MIEIKQTEIFRKWRTRLKDERARILIASRLDRLAFGLAGDAEPVGQGVSELRIHHGPGYRIYFQKRGSTIIVLLCGGDKS
TQAKDIKIAKRLADEWSE

Download         Length: 297 bp

>T118013 NZ_CP035503:97423-97719 [Rhodoferax sediminis]
ATGATCGAGATAAAACAAACGGAAATATTCAGGAAGTGGCGAACCCGACTCAAGGACGAACGGGCGCGCATCTTGATTGC
ATCCCGTCTGGACCGCCTCGCCTTTGGTCTTGCGGGCGATGCGGAACCCGTGGGGCAGGGAGTCAGCGAATTGCGTATCC
ACCATGGCCCCGGATACCGCATCTACTTCCAGAAACGGGGAAGCACGATCATTGTCCTGCTGTGCGGCGGTGACAAAAGC
ACGCAGGCGAAGGACATCAAAATTGCGAAGCGTCTGGCGGATGAATGGAGCGAATGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 10914.38 Da        Isoelectric Point: 4.5338

>AT118013 WP_210411676.1 NZ_CP035503:97703-98014 [Rhodoferax sediminis]
MNGANEMTEKLTTYDPAEDLTSDEAMALFMAEAFQTNDAGYIAHALGVVARAKGMTQIAGQTGLSREQLYRSFSENGNPT
LKTTLAVMKALGIELTAKVPAAA

Download         Length: 312 bp

>AT118013 NZ_CP035503:97703-98014 [Rhodoferax sediminis]
ATGAATGGAGCGAATGAAATGACTGAAAAACTGACCACCTATGATCCCGCCGAGGATTTGACCTCTGACGAAGCGATGGC
GCTCTTCATGGCCGAGGCGTTCCAGACGAATGACGCCGGCTACATCGCGCATGCGTTGGGGGTCGTCGCCCGGGCCAAAG
GAATGACGCAAATTGCGGGGCAAACCGGGCTTTCCCGCGAGCAGCTTTACCGCTCCTTCAGCGAGAACGGCAATCCAACC
CTGAAGACAACCTTGGCGGTCATGAAGGCCCTGGGCATCGAGCTGACTGCCAAAGTTCCGGCTGCCGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References