Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 52273..52531 Replicon chromosome
Accession NZ_CP035486
Organism Escherichia coli strain NissleGFP_pZE21

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag EUJ32_RS00270 Protein ID WP_000809168.1
Coordinates 52273..52425 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 52474..52531 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EUJ32_RS00250 47518..48231 - 714 WP_001102391.1 acidic protein MsyB -
EUJ32_RS00255 48257..48661 - 405 WP_000843687.1 DUF2541 family protein -
EUJ32_RS00260 49033..50949 + 1917 WP_000516135.1 molecular chaperone DnaK -
EUJ32_RS00265 51038..52168 + 1131 WP_001118465.1 molecular chaperone DnaJ -
EUJ32_RS00270 52273..52425 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 52474..52531 + 58 - - Antitoxin
EUJ32_RS00275 53040..53801 + 762 WP_001274832.1 hypothetical protein -
EUJ32_RS00280 53821..55314 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
EUJ32_RS00285 55443..56702 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T117943 WP_000809168.1 NZ_CP035486:c52425-52273 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T117943 NZ_CP035486:c52425-52273 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT117943 NZ_CP035486:52474-52531 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References