Detailed information of TA system TA117768

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2549929..2550254
• Replicon: chromosome
• Accession: NZ_CP035411
• Organism: Bacillus subtilis strain SRCM103622

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: ETK71_RS13215
• Protein ID: WP_004398662.1
• Coordinates: 2549929..2550108 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2550032..2550254 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ETK71_RS13205	2549155..2549292	-	138	WP_021480099.1	hypothetical protein	-
ETK71_RS13210	2549334..2549783	-	450	WP_032722171.1	phage portal protein	-
ETK71_RS13215	2549929..2550108	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2550032..2550254	-	223	NuclAT_0	-	Antitoxin
-	2550032..2550254	-	223	NuclAT_0	-	Antitoxin
-	2550032..2550254	-	223	NuclAT_0	-	Antitoxin
-	2550032..2550254	-	223	NuclAT_0	-	Antitoxin
ETK71_RS13220	2550488..2550577	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
ETK71_RS13225	2550831..2551274	-	444	WP_003229930.1	phage tail tube protein	-
ETK71_RS13230	2551277..2552677	-	1401	WP_129138171.1	phage tail sheath family protein	-
ETK71_RS13235	2552678..2552869	-	192	WP_032679171.1	hypothetical protein	-
ETK71_RS13240	2552866..2553303	-	438	WP_015714315.1	hypothetical protein	-
ETK71_RS13245	2553316..2553819	-	504	WP_015714316.1	HK97 gp10 family phage protein	-
ETK71_RS13250	2553816..2554178	-	363	WP_015714317.1	YqbH/XkdH family protein	-
ETK71_RS13255	2554175..2554570	-	396	WP_015714318.1	DUF3199 family protein	-
ETK71_RS13260	2554575..2554886	-	312	WP_015714319.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2527083..2573927	46844

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T117768 WP_004398662.1 NZ_CP035411:2549929-2550108 [Bacillus subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T117768 NZ_CP035411:2549929-2550108 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin

Nucleotide

• Length: 223 bp

>AT117768 NZ_CP035411:c2550254-2550032 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin