Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4765727..4766343 Replicon chromosome
Accession NZ_CP035385
Organism Enterobacter hormaechei strain S11_16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EQ802_RS23340 Protein ID WP_080298797.1
Coordinates 4765727..4766098 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag EQ802_RS23345 Protein ID WP_023298920.1
Coordinates 4766101..4766343 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ802_RS23325 4763227..4764129 + 903 WP_063148344.1 formate dehydrogenase subunit beta -
EQ802_RS23330 4764126..4764761 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
EQ802_RS23335 4764758..4765687 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
EQ802_RS23340 4765727..4766098 - 372 WP_080298797.1 type II toxin-antitoxin system VapC family toxin Toxin
EQ802_RS23345 4766101..4766343 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
EQ802_RS23350 4766543..4767463 + 921 WP_063148343.1 alpha/beta hydrolase -
EQ802_RS23355 4767472..4768413 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
EQ802_RS23360 4768458..4768895 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
EQ802_RS23365 4768892..4769773 - 882 WP_023298923.1 virulence factor BrkB family protein -
EQ802_RS23370 4769767..4770366 - 600 WP_023315056.1 glucose-1-phosphatase -
EQ802_RS23375 4770485..4771285 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4755949..4767463 11514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13612.66 Da        Isoelectric Point: 6.4865

>T117728 WP_080298797.1 NZ_CP035385:c4766098-4765727 [Enterobacter hormaechei]
MEHMAVYDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T117728 NZ_CP035385:c4766098-4765727 [Enterobacter hormaechei]
ATGGAGCACATGGCTGTGTATGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGGGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT117728 WP_023298920.1 NZ_CP035385:c4766343-4766101 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT117728 NZ_CP035385:c4766343-4766101 [Enterobacter hormaechei]
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References