Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2434301..2434865 Replicon chromosome
Accession NZ_CP035382
Organism Leclercia adecarboxylata strain R25

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ES815_RS12605 Protein ID WP_142488093.1
Coordinates 2434560..2434865 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ES815_RS12600 Protein ID WP_106995684.1
Coordinates 2434301..2434573 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES815_RS12575 2429737..2430078 + 342 WP_142488088.1 hypothetical protein -
ES815_RS12580 2430194..2430661 + 468 WP_142488089.1 MarR family transcriptional regulator -
ES815_RS12585 2430661..2431728 + 1068 WP_142488090.1 HlyD family secretion protein -
ES815_RS12590 2431734..2432801 + 1068 WP_142488091.1 DUF2955 domain-containing protein -
ES815_RS12595 2432805..2434085 - 1281 WP_142488092.1 DUF445 domain-containing protein -
ES815_RS12600 2434301..2434573 + 273 WP_106995684.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ES815_RS12605 2434560..2434865 + 306 WP_142488093.1 type II toxin-antitoxin system YafQ family toxin Toxin
ES815_RS12610 2434903..2435559 - 657 WP_142488094.1 LysE family translocator -
ES815_RS12615 2435607..2436350 - 744 WP_142488095.1 AraC family transcriptional regulator -
ES815_RS12620 2436510..2436932 + 423 WP_142488096.1 hypothetical protein -
ES815_RS12630 2437375..2438067 + 693 WP_142488097.1 hypothetical protein -
ES815_RS12640 2438318..2438797 + 480 WP_142488099.1 type VI secretion system tube protein Hcp -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-66)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11588.18 Da        Isoelectric Point: 7.4629

>T117682 WP_142488093.1 NZ_CP035382:2434560-2434865 [Leclercia adecarboxylata]
MGKSKRAPLPYRSDYTKTFVKAWDRYNKAGRRDMHATAEIMSLVLSGNPIPSEYSDHPLTGDMQGFRELHIGGDYLLVYR
IDDKKHLVVFTDLGTHAELFE

Download         Length: 306 bp

>T117682 NZ_CP035382:2434560-2434865 [Leclercia adecarboxylata]
ATGGGAAAGAGTAAACGCGCGCCACTTCCGTACCGTTCTGATTACACTAAAACCTTTGTTAAAGCCTGGGATCGCTACAA
CAAAGCAGGCCGGAGAGATATGCATGCCACGGCGGAGATTATGTCGCTGGTGCTCTCCGGTAATCCCATCCCTTCTGAGT
ACAGCGATCATCCCCTGACAGGCGATATGCAAGGCTTCCGCGAGCTGCATATTGGCGGTGACTATCTGTTGGTTTATCGG
ATCGATGATAAAAAGCATCTGGTCGTGTTTACCGACCTGGGCACCCACGCAGAGCTTTTTGAATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10066.30 Da        Isoelectric Point: 4.8483

>AT117682 WP_106995684.1 NZ_CP035382:2434301-2434573 [Leclercia adecarboxylata]
MDSVIRSRIDSELKAQAGSVLESCGLTWSTAIRLFAEQIVKNEGIPFEVTRKPTARLRNAMREAEDISTHQNGRFDGVDQ
LMESLNDGKE

Download         Length: 273 bp

>AT117682 NZ_CP035382:2434301-2434573 [Leclercia adecarboxylata]
ATGGATTCCGTAATCCGATCGCGTATCGACAGCGAGCTCAAAGCTCAGGCGGGTTCTGTCCTTGAGAGCTGTGGCTTAAC
CTGGAGCACGGCGATACGCCTGTTCGCCGAGCAGATTGTCAAAAATGAAGGGATCCCGTTTGAGGTGACCCGCAAACCCA
CCGCACGGTTACGCAATGCGATGCGCGAAGCCGAAGATATTTCCACCCACCAGAACGGACGCTTTGATGGTGTTGACCAG
CTCATGGAGAGCTTAAACGATGGGAAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References