Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1605562..1606074 Replicon chromosome
Accession NZ_CP035254
Organism Streptococcus pneumoniae strain TVO_1901932

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH26_RS08065 Protein ID WP_000924721.1
Coordinates 1605562..1605816 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EQH26_RS08070 Protein ID WP_000388572.1
Coordinates 1605820..1606074 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH26_RS08050 (EQH26_08505) 1602663..1602977 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH26_RS08055 (EQH26_08510) 1603002..1603628 - 627 WP_000775037.1 guanylate kinase -
EQH26_RS08060 (EQH26_08515) 1603758..1605371 - 1614 WP_000404940.1 ribonuclease Y -
EQH26_RS08065 (EQH26_08520) 1605562..1605816 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH26_RS08070 (EQH26_08525) 1605820..1606074 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH26_RS08075 (EQH26_08530) 1606312..1607409 - 1098 WP_000156333.1 nucleotidyltransferase -
EQH26_RS08080 (EQH26_08535) 1607419..1608165 - 747 WP_000605154.1 class I SAM-dependent methyltransferase -
EQH26_RS08085 (EQH26_08540) 1608268..1608621 - 354 WP_001003001.1 ribosome silencing factor -
EQH26_RS08090 (EQH26_08545) 1608634..1609134 - 501 WP_000844713.1 cysteine hydrolase family protein -
EQH26_RS08095 (EQH26_08550) 1609135..1609728 - 594 WP_000331230.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH26_RS08100 (EQH26_08555) 1609728..1610357 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
EQH26_RS08105 (EQH26_08560) 1610409..1610720 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117479 WP_000924721.1 NZ_CP035254:c1605816-1605562 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117479 NZ_CP035254:c1605816-1605562 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT117479 WP_000388572.1 NZ_CP035254:c1606074-1605820 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT117479 NZ_CP035254:c1606074-1605820 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References