Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1645308..1645820 Replicon chromosome
Accession NZ_CP035239
Organism Streptococcus pneumoniae strain TVO_TIGR4

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag EQH41_RS08125 Protein ID WP_000924721.1
Coordinates 1645308..1645562 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag EQH41_RS08130 Protein ID WP_000388572.1
Coordinates 1645566..1645820 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQH41_RS08110 (EQH41_08650) 1642409..1642723 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
EQH41_RS08115 (EQH41_08655) 1642748..1643374 - 627 WP_000775037.1 guanylate kinase -
EQH41_RS08120 (EQH41_08660) 1643504..1645117 - 1614 WP_000404940.1 ribonuclease Y -
EQH41_RS08125 (EQH41_08665) 1645308..1645562 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
EQH41_RS08130 (EQH41_08670) 1645566..1645820 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EQH41_RS08135 (EQH41_08675) 1646058..1647155 - 1098 WP_000156358.1 nucleotidyltransferase -
EQH41_RS08140 (EQH41_08680) 1647165..1647911 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
EQH41_RS08145 (EQH41_08685) 1648014..1648367 - 354 WP_001003023.1 ribosome silencing factor -
EQH41_RS08150 (EQH41_08690) 1648380..1648880 - 501 WP_000844707.1 cysteine hydrolase family protein -
EQH41_RS08155 (EQH41_08695) 1648881..1649474 - 594 WP_000121667.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
EQH41_RS08160 (EQH41_08700) 1649474..1650103 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
EQH41_RS08165 (EQH41_08705) 1650155..1650466 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T117444 WP_000924721.1 NZ_CP035239:c1645562-1645308 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T117444 NZ_CP035239:c1645562-1645308 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT117444 WP_000388572.1 NZ_CP035239:c1645820-1645566 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT117444 NZ_CP035239:c1645820-1645566 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References