Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 39786..40438 Replicon plasmid p3-AD3
Accession NZ_CP034904
Organism Roseomonas mucosa strain AD3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RMP42_RS21310 Protein ID WP_265887037.1
Coordinates 39786..40178 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RMP42_RS21315 Protein ID WP_265886964.1
Coordinates 40190..40438 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RMP42_RS21290 (RMP42_05086a) 34935..35477 + 543 WP_265886961.1 hypothetical protein -
RMP42_RS21295 (RMP42_05087a) 35628..35990 + 363 WP_265887036.1 hypothetical protein -
RMP42_RS21300 (RMP42_05088a) 35996..36679 + 684 WP_265886962.1 HNH endonuclease -
RMP42_RS21305 (RMP42_05089a) 36676..39735 + 3060 WP_265886963.1 ATP-binding protein -
RMP42_RS21310 (RMP42_05789) 39786..40178 - 393 WP_265887037.1 type II toxin-antitoxin system VapC family toxin Toxin
RMP42_RS21315 (RMP42_05788) 40190..40438 - 249 WP_265886964.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RMP42_RS21320 (RMP42_03950a) 40595..41068 + 474 WP_265886965.1 DotD/TraH family lipoprotein -
RMP42_RS21325 (RMP42_03949a) 41061..42026 + 966 WP_265886966.1 type IV secretory system conjugative DNA transfer family protein -
RMP42_RS21330 (RMP42_03948a) 42023..43192 + 1170 WP_265886967.1 ATPase, T2SS/T4P/T4SS family -
RMP42_RS21335 (RMP42_03947a) 43192..43440 + 249 WP_198382690.1 IcmT/TraK family protein -
RMP42_RS21340 (RMP42_03946b) 43437..44210 + 774 WP_265886968.1 hypothetical protein -
RMP42_RS21345 (RMP42_00104b) 44267..44836 - 570 WP_265886969.1 DsbE family thiol:disulfide interchange protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..156070 156070


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

SpoVT-AbrB domain

(14-51)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13656.81 Da        Isoelectric Point: 6.9521

>T116922 WP_265887037.1 NZ_CP034904:c40178-39786 [Roseomonas mucosa]
MLDTNIVSDMIRNPTGTAARKARAVGAGVCVSIIVAAELRYGCAKKGSSRLLERVEAFLGAVPVMPLDVPADAEYGGLRA
ELEAAGQPIGGNDLLIAAHAYALEATLVTANVAEFRRVRGLRVENWLVPG

Download         Length: 393 bp

>T116922 NZ_CP034904:c40178-39786 [Roseomonas mucosa]
ATGTTGGATACCAACATCGTCAGCGACATGATCCGTAATCCGACAGGGACGGCAGCGCGAAAAGCACGGGCAGTGGGGGC
GGGGGTCTGCGTCAGCATCATCGTCGCCGCAGAGCTGCGTTACGGCTGCGCCAAAAAAGGATCTTCTCGGCTCCTAGAGC
GGGTTGAGGCATTCCTGGGTGCAGTGCCAGTGATGCCGCTGGATGTTCCGGCCGATGCTGAGTACGGCGGGTTGCGGGCG
GAACTGGAAGCCGCCGGCCAGCCGATCGGCGGGAATGATCTGCTGATCGCCGCTCATGCTTACGCACTGGAGGCGACCCT
CGTGACAGCGAACGTAGCGGAGTTCCGACGGGTACGCGGACTGCGGGTCGAGAACTGGTTGGTCCCTGGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9285.59 Da        Isoelectric Point: 4.4367

>AT116922 WP_265886964.1 NZ_CP034904:c40438-40190 [Roseomonas mucosa]
MPQVTPAPRQVRLFRNNRNQAVRIPVEFELPGTEAIISRDGDRLILEPVRSKSLSLLLDSWEPLEEALPEVDDPPPAARD
VF

Download         Length: 249 bp

>AT116922 NZ_CP034904:c40438-40190 [Roseomonas mucosa]
ATGCCTCAGGTCACCCCCGCACCCCGACAGGTACGGCTGTTCCGCAACAATCGGAACCAGGCCGTTCGAATACCCGTGGA
GTTCGAGCTCCCTGGTACTGAAGCCATCATCAGCCGGGACGGCGACCGCCTCATCCTCGAGCCTGTTCGCTCCAAAAGTC
TGTCCTTGCTGCTCGATAGTTGGGAACCTCTGGAAGAAGCCCTGCCGGAAGTCGACGATCCGCCACCCGCCGCACGGGAT
GTCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References