Detailed information of TA system TA116677

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4904063..4904288
• Replicon: chromosome
• Accession: NZ_CP034797
• Organism: Escherichia coli strain 08-3918

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: AYP37_RS25005
• Protein ID: WP_000813263.1
• Coordinates: 4904133..4904288 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4904063..4904121 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYP37_RS24970	4899338..4900429	+	1092	WP_001205823.1	hypothetical protein	-
AYP37_RS24975	4900436..4901182	+	747	WP_000788745.1	ATP-binding protein	-
AYP37_RS24980	4901204..4901974	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
AYP37_RS24985	4901990..4902403	+	414	WP_001151233.1	DUF977 family protein	-
AYP37_RS24990	4902755..4903528	-	774	WP_000160650.1	alpha/beta hydrolase	-
-	4904063..4904121	-	59	-	-	Antitoxin
AYP37_RS25005	4904133..4904288	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
AYP37_RS25010	4904456..4904734	+	279	WP_001341388.1	hypothetical protein	-
AYP37_RS25015	4904736..4905785	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
AYP37_RS25020	4905798..4906169	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
AYP37_RS25025	4906159..4906530	+	372	WP_000090264.1	antitermination protein	-
AYP37_RS25030	4906682..4907500	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
AYP37_RS25035	4907787..4907983	+	197	Protein_4658	TrmB family transcriptional regulator	-
AYP37_RS25040	4908121..4908834	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T116677 WP_000813263.1 NZ_CP034797:4904133-4904288 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T116677 NZ_CP034797:4904133-4904288 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT116677 NZ_CP034797:c4904121-4904063 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin