Detailed information of TA system TA116350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 2447218..2447963
• Replicon: chromosome
• Accession: NZ_CP034668
• Organism: Proteus vulgaris strain PvSC3

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: EKQ45_RS13350
• Protein ID: WP_075673025.1
• Coordinates: 2447472..2447963 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: EKQ45_RS13345
• Protein ID: WP_075673024.1
• Coordinates: 2447218..2447484 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKQ45_RS13310	2442879..2443361	+	483	WP_006533151.1	flagellar basal body-associated protein FliL	-
EKQ45_RS13315	2443367..2444398	+	1032	WP_023581831.1	flagellar motor switch protein FliM	-
EKQ45_RS13320	2444391..2444801	+	411	WP_006533153.1	flagellar motor switch protein FliN	-
EKQ45_RS13325	2444805..2445251	+	447	WP_075673022.1	flagellar biosynthetic protein FliO	-
EKQ45_RS13330	2445308..2446021	+	714	WP_171455369.1	flagellar type III secretion system pore protein FliP	-
EKQ45_RS13335	2446037..2446306	+	270	WP_069367481.1	flagellar biosynthesis protein FliQ	-
EKQ45_RS13340	2446312..2447094	+	783	WP_075673023.1	flagellar type III secretion system protein FliR	-
EKQ45_RS13345	2447218..2447484	+	267	WP_075673024.1	DUF1778 domain-containing protein	Antitoxin
EKQ45_RS13350	2447472..2447963	+	492	WP_075673025.1	GNAT family N-acetyltransferase	Toxin
EKQ45_RS13355	2448049..2448993	-	945	WP_087802138.1	flagellar hook-associated protein FlgL	-
EKQ45_RS13360	2449018..2450661	-	1644	WP_075673027.1	flagellar hook-associated protein FlgK	-
EKQ45_RS13365	2450780..2451766	-	987	WP_099660621.1	flagellar assembly peptidoglycan hydrolase FlgJ	-
EKQ45_RS13370	2451766..2452872	-	1107	WP_075673029.1	flagellar basal body P-ring protein FlgI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (22-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-87)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18228.15 Da
• Isoelectric Point: 10.3194

>T116350 WP_075673025.1 NZ_CP034668:2447472-2447963 [Proteus vulgaris]
MGKVTAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFVVCEKNKKRVVGYYSLATGSVNHTEAMSHIRRNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKHFYLHHGFKASSTQDKILFLALK
KKI

Nucleotide

• Length: 492 bp

>T116350 NZ_CP034668:2447472-2447963 [Proteus vulgaris]
ATGGGAAAAGTAACAGCACCTGAGCCGTTATCAAACTCACATGAAGTGGCTGATTTTTATAGTAGTGAAAATGTATTAGA
TAACTGGATAAAACAAAGAGGTTTAAAAAACCAATTTTTAGGTGCATCCCGTACATTTGTGGTCTGTGAAAAAAATAAAA
AACGTGTTGTTGGGTACTATTCTTTAGCAACAGGTAGTGTTAACCATACTGAAGCAATGAGTCATATTCGTCGCAATATG
CCAGACCCAATACCCGTGATCATTTTAGCTAGACTTGCTGTTGATAAAACTTTTCATGGAAAAGGTCTTGGTGCCGATTT
GTTAAGAGATGCAGTTTTGCGTTGTCATCATGTAGCTGAAAACATTGGTGTTAGAGCGATTATGGTTCATGCTTTAACTG
AAAACGCAAAACATTTCTACCTTCATCATGGTTTCAAAGCTTCTTCGACTCAAGACAAAATCTTATTCTTAGCACTAAAA
AAGAAAATATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10111.62 Da
• Isoelectric Point: 4.5256

>AT116350 WP_075673024.1 NZ_CP034668:2447218-2447484 [Proteus vulgaris]
MKADVQLNIRAKESQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Nucleotide

• Length: 267 bp

>AT116350 NZ_CP034668:2447218-2447484 [Proteus vulgaris]
ATGAAAGCTGATGTACAACTCAATATTCGCGCTAAAGAATCACAACGCGCACTTATTGATACTGCTGCTGAAATTCTCCA
TAAATCTCGTACTGACTTTATTCTTGAGACAGCATGCCAAGCTGCTGAAGACGTCATTTTAGACCGTAGAACCTTTAATT
TAAATGATGCTCAATATGCGGAATTTATAGAAATTATTGATGCGCCGGTTGATATTGACCCTGCTCTTGAAAAGTTATTA
ATGAGAAAACCATTATGGGAAAAGTAA