Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 294826..295448 Replicon chromosome
Accession NZ_CP034338
Organism Pseudomonas entomophila strain 1257

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EJA05_RS01460 Protein ID WP_125857127.1
Coordinates 294826..295017 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EJA05_RS01465 Protein ID WP_125857128.1
Coordinates 295035..295448 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJA05_RS01450 291537..292856 + 1320 WP_125462237.1 OprD family porin -
EJA05_RS01455 292887..294557 - 1671 WP_125857126.1 FMN-binding glutamate synthase family protein -
EJA05_RS01460 294826..295017 + 192 WP_125857127.1 type II toxin-antitoxin system HicA family toxin Toxin
EJA05_RS01465 295035..295448 + 414 WP_125857128.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EJA05_RS01470 295476..296195 - 720 WP_125857129.1 response regulator transcription factor -
EJA05_RS01475 296348..297490 - 1143 WP_125857130.1 nitrite reductase, copper-containing -
EJA05_RS01480 297666..297881 + 216 WP_125857131.1 hypothetical protein -
EJA05_RS01490 298127..298375 - 249 WP_110992228.1 hypothetical protein -
EJA05_RS01495 299031..299390 + 360 WP_125462244.1 QacE family quaternary ammonium compound efflux SMR transporter -
EJA05_RS01500 299384..299701 + 318 WP_125462245.1 multidrug/spermidine efflux SMR transporter subunit MdtI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6997.17 Da        Isoelectric Point: 11.0104

>T115749 WP_125857127.1 NZ_CP034338:294826-295017 [Pseudomonas entomophila]
MNSRVMISVIEADGWYLVRSKGSHHHFKHPHKAGLVTIPHPKKDLLPATAASILRQARIGYAS

Download         Length: 192 bp

>T115749 NZ_CP034338:294826-295017 [Pseudomonas entomophila]
ATGAACAGCCGCGTAATGATTTCGGTGATCGAGGCCGATGGTTGGTACCTGGTGCGATCCAAGGGCAGCCACCATCACTT
CAAGCACCCCCACAAGGCTGGGCTGGTGACCATCCCGCACCCGAAGAAGGACCTGCTGCCCGCCACTGCGGCCAGCATCC
TGCGCCAGGCGCGGATCGGCTACGCCAGCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14898.98 Da        Isoelectric Point: 4.4314

>AT115749 WP_125857128.1 NZ_CP034338:295035-295448 [Pseudomonas entomophila]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDDAIAMAREAIEGHLELLAQDGEEIPKASKVSVHAANPDYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDAYVKNHPEQKSRSGFLAEAALRILQGDCK

Download         Length: 414 bp

>AT115749 NZ_CP034338:295035-295448 [Pseudomonas entomophila]
ATGTTATTCCCCATCGCCATCCTGCCCGGCGACGATCAGCACGCCTGGGGCGTGGAAGTCCCGGACATCCCGGGCTGCTT
TTCGGCCGGTGAAGACCTCGATGACGCCATTGCCATGGCCCGCGAGGCCATCGAGGGCCACCTCGAACTGCTCGCCCAGG
ACGGCGAGGAAATCCCCAAGGCCAGCAAGGTGAGCGTGCATGCGGCCAACCCTGACTACGCCGGATGCACCTGGGCACTC
ATCGACATCGATATCACCCGCTACCTGGGTAAGGCCGAGAAGCTCAACATCACACTGCCGGCCTACCTGCTCACCCGCAT
TGATGCCTACGTGAAGAACCATCCGGAGCAGAAAAGCCGCTCGGGCTTCCTGGCTGAAGCGGCGCTGAGAATCCTGCAGG
GCGACTGCAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References