Detailed information of TA system TA115694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1630157..1630685
• Replicon: chromosome
• Accession: NZ_CP034295
• Organism: Vibrio parahaemolyticus strain 20140829008-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EHC66_RS24375
• Protein ID: WP_108653690.1
• Coordinates: 1630395..1630685 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EHC66_RS24370
• Protein ID: WP_025611568.1
• Coordinates: 1630157..1630405 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC66_RS24340	1625968..1626333	+	366	WP_031428075.1	hypothetical protein	-
EHC66_RS24345	1626677..1627615	-	939	WP_031428077.1	DMT family transporter	-
EHC66_RS24350	1627719..1628600	+	882	WP_108653693.1	LysR family transcriptional regulator	-
EHC66_RS24355	1628804..1629292	-	489	WP_108653692.1	DUF523 domain-containing protein	-
EHC66_RS24360	1629410..1629946	-	537	WP_108653691.1	ClbS/DfsB family four-helix bundle protein	-
EHC66_RS24365	1630014..1630082	-	69	WP_080254664.1	DUF3265 domain-containing protein	-
EHC66_RS24370	1630157..1630405	+	249	WP_025611568.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EHC66_RS24375	1630395..1630685	+	291	WP_108653690.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHC66_RS24380	1630838..1631107	-	270	WP_029865924.1	Txe/YoeB family addiction module toxin	-
EHC66_RS24385	1631100..1631354	-	255	WP_029865959.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
EHC66_RS24390	1631456..1631548	-	93	WP_140321407.1	DUF3265 domain-containing protein	-
EHC66_RS24395	1631663..1632631	+	969	WP_159404068.1	IS30-like element ISVa6 family transposase	-
EHC66_RS24400	1633097..1633246	-	150	WP_108654761.1	DUF3265 domain-containing protein	-
EHC66_RS24405	1633221..1633688	-	468	WP_108654760.1	NUDIX domain-containing protein	-
EHC66_RS24410	1633794..1634786	-	993	WP_108654759.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1595150..1642793	47643
	-	flank	IS/Tn	-	-	1631855..1632631	776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11300.24 Da
• Isoelectric Point: 10.5339

>T115694 WP_108653690.1 NZ_CP034295:1630395-1630685 [Vibrio parahaemolyticus]
MTYRLDFKKSALKEWKKLGSTLQQQFKKKLIDRLDNPHVPASKLSGTDNMYKIKLRQSGYRLVYKVEDDVIIVTILAVGK
HERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T115694 NZ_CP034295:1630395-1630685 [Vibrio parahaemolyticus]
ATGACCTATAGACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTACAACAACAATTTAA
GAAAAAGCTAATCGACCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAACTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGACGTCATCATTGTAACCATCTTAGCAGTTGGAAAA
CACGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9109.39 Da
• Isoelectric Point: 3.9610

>AT115694 WP_025611568.1 NZ_CP034295:1630157-1630405 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAETYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT115694 NZ_CP034295:1630157-1630405 [Vibrio parahaemolyticus]
ATGACCACAAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAATCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGTGTACCTGCCGAAACGTATGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCCAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAG