Detailed information of TA system TA115688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1619195..1619723
• Replicon: chromosome
• Accession: NZ_CP034290
• Organism: Vibrio parahaemolyticus strain 20140722001-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EHC64_RS24720
• Protein ID: WP_108653690.1
• Coordinates: 1619433..1619723 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EHC64_RS24715
• Protein ID: WP_025611568.1
• Coordinates: 1619195..1619443 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHC64_RS24685	1615006..1615371	+	366	WP_031428075.1	hypothetical protein	-
EHC64_RS24690	1615715..1616653	-	939	WP_031428077.1	DMT family transporter	-
EHC64_RS24695	1616757..1617638	+	882	WP_108653693.1	LysR family transcriptional regulator	-
EHC64_RS24700	1617842..1618330	-	489	WP_108653692.1	DUF523 domain-containing protein	-
EHC64_RS24705	1618448..1618984	-	537	WP_108653691.1	ClbS/DfsB family four-helix bundle protein	-
EHC64_RS24710	1619052..1619120	-	69	WP_080254664.1	DUF3265 domain-containing protein	-
EHC64_RS24715	1619195..1619443	+	249	WP_025611568.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EHC64_RS24720	1619433..1619723	+	291	WP_108653690.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EHC64_RS24725	1619876..1620145	-	270	WP_029865924.1	Txe/YoeB family addiction module toxin	-
EHC64_RS24730	1620138..1620392	-	255	WP_029865959.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
EHC64_RS24735	1620494..1620586	-	93	WP_140321407.1	DUF3265 domain-containing protein	-
EHC64_RS24740	1620701..1621669	+	969	WP_159404068.1	IS30-like element ISVa6 family transposase	-
EHC64_RS24745	1622135..1622284	-	150	WP_108654761.1	DUF3265 domain-containing protein	-
EHC64_RS24750	1622259..1622726	-	468	WP_108654760.1	NUDIX domain-containing protein	-
EHC64_RS24755	1622832..1623824	-	993	WP_108654759.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1584188..1631831	47643
	-	flank	IS/Tn	-	-	1620893..1621669	776

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11300.24 Da
• Isoelectric Point: 10.5339

>T115688 WP_108653690.1 NZ_CP034290:1619433-1619723 [Vibrio parahaemolyticus]
MTYRLDFKKSALKEWKKLGSTLQQQFKKKLIDRLDNPHVPASKLSGTDNMYKIKLRQSGYRLVYKVEDDVIIVTILAVGK
HERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T115688 NZ_CP034290:1619433-1619723 [Vibrio parahaemolyticus]
ATGACCTATAGACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTACAACAACAATTTAA
GAAAAAGCTAATCGACCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAACTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGACGTCATCATTGTAACCATCTTAGCAGTTGGAAAA
CACGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9109.39 Da
• Isoelectric Point: 3.9610

>AT115688 WP_025611568.1 NZ_CP034290:1619195-1619443 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAETYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT115688 NZ_CP034290:1619195-1619443 [Vibrio parahaemolyticus]
ATGACCACAAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAATCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGTGTACCTGCCGAAACGTATGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCCAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAG