Detailed information of TA system TA115588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 602287..602846
• Replicon: chromosome
• Accession: NZ_CP034241
• Organism: Aliivibrio salmonicida strain VS224

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B6ERG4
• Locus tag: EIJ81_RS20250
• Protein ID: WP_012551866.1
• Coordinates: 602532..602846 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B6ERG3
• Locus tag: EIJ81_RS20245
• Protein ID: WP_012551865.1
• Coordinates: 602287..602541 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIJ81_RS20215	598106..598861	+	756	WP_012551859.1	membrane protein	-
EIJ81_RS20220	599063..599776	+	714	WP_012551860.1	RES family NAD+ phosphorylase	-
EIJ81_RS20225	599934..600368	+	435	WP_044583568.1	GNAT family N-acetyltransferase	-
EIJ81_RS20230	600599..600868	+	270	WP_044583569.1	DUF1778 domain-containing protein	-
EIJ81_RS20235	600865..601395	+	531	WP_012551863.1	GNAT family N-acetyltransferase	-
EIJ81_RS20240	601404..602099	+	696	WP_012551864.1	hypothetical protein	-
EIJ81_RS20245	602287..602541	+	255	WP_012551865.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EIJ81_RS20250	602532..602846	+	315	WP_012551866.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EIJ81_RS20255	603090..603440	+	351	WP_012551867.1	cupin domain-containing protein	-
EIJ81_RS20260	603680..604150	+	471	WP_012551868.1	hypothetical protein	-
EIJ81_RS20265	604143..604745	+	603	WP_012551869.1	putative adenosine monophosphate-protein transferase Fic	-
EIJ81_RS20275	605437..605706	-	270	WP_012551870.1	type II toxin-antitoxin system YafQ family toxin	-
EIJ81_RS20280	605699..605977	-	279	WP_012551871.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
EIJ81_RS20285	606204..607796	-	1593	WP_012551872.1	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	593550..615412	21862

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-65)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12198.11 Da
• Isoelectric Point: 4.5467

>T115588 WP_012551866.1 NZ_CP034241:602532-602846 [Aliivibrio salmonicida]
MAVINWTESALLDLDEIAEYIAINNILAAKALVKSVFHCVERLEDFPFSGRNVPELPHLDYREIVLPPCRIFYKVTNDDV
VYILYVMREERELRQFVLNDRGLQ

Nucleotide

• Length: 315 bp

>T115588 NZ_CP034241:602532-602846 [Aliivibrio salmonicida]
ATGGCTGTAATTAATTGGACTGAATCAGCATTACTAGATTTAGACGAAATTGCGGAATACATAGCCATTAATAATATCTT
AGCGGCTAAAGCGTTAGTTAAGTCAGTTTTTCATTGTGTTGAACGTTTGGAAGACTTTCCATTTTCAGGTCGTAATGTGC
CGGAGCTTCCTCATTTAGATTATCGTGAAATAGTGTTACCGCCATGTCGTATCTTCTACAAAGTAACCAATGACGATGTT
GTGTATATCCTTTACGTTATGAGAGAAGAGCGCGAGTTACGCCAATTTGTTCTTAATGACCGTGGTTTGCAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9590.14 Da
• Isoelectric Point: 7.3180

>AT115588 WP_012551865.1 NZ_CP034241:602287-602541 [Aliivibrio salmonicida]
MKVELVTTLKRQATKILSELHASKEPVLITEHGQPSAYLLDVDDYEFMQKRIAILEGIARGEKAISDNRVVSHEVAKEKM
NKWL

Nucleotide

• Length: 255 bp

>AT115588 NZ_CP034241:602287-602541 [Aliivibrio salmonicida]
ATGAAAGTTGAATTAGTCACTACATTGAAGCGTCAAGCTACTAAAATTCTTTCTGAGCTTCATGCCTCAAAAGAGCCGGT
ATTAATTACAGAGCATGGTCAACCATCTGCGTATTTGTTGGATGTCGATGATTATGAATTTATGCAAAAACGTATTGCCA
TTCTTGAAGGCATCGCCCGTGGTGAAAAAGCTATTTCAGATAATCGTGTCGTTTCTCATGAAGTAGCAAAAGAGAAGATG
AATAAATGGCTGTAA

Structures

Toxin

• AlphaFold DB: B6ERG4

Antitoxin

• AlphaFold DB: B6ERG3