Detailed information of TA system TA115583

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 1666858..1667633
• Replicon: chromosome
• Accession: NZ_CP034240
• Organism: Aliivibrio salmonicida strain VS224

Toxin (Protein)

• Gene name: -
• Uniprot ID: B6EME0
• Locus tag: EIJ81_RS09935
• Protein ID: WP_012550273.1
• Coordinates: 1667130..1667633 (+)
• Length: 168 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EIJ81_RS09930
• Protein ID: WP_044583260.1
• Coordinates: 1666858..1667133 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EIJ81_RS09915	1662595..1663764	+	1170	WP_012550270.1	S-methyl-5-thioribose kinase	-
EIJ81_RS09920	1663827..1665473	-	1647	WP_173362140.1	methyl-accepting chemotaxis protein	-
EIJ81_RS09925	1665707..1666663	+	957	WP_012549047.1	IS30-like element ISVsa7 family transposase	-
EIJ81_RS09930	1666858..1667133	+	276	WP_044583260.1	DUF1778 domain-containing protein	Antitoxin
EIJ81_RS09935	1667130..1667633	+	504	WP_012550273.1	GNAT family N-acetyltransferase	Toxin
EIJ81_RS09940	1667922..1668167	-	246	WP_012550274.1	hypothetical protein	-
EIJ81_RS09945	1668157..1668420	-	264	WP_012550275.1	BrnT family toxin	-
EIJ81_RS09950	1668600..1669718	-	1119	WP_012550276.1	hypothetical protein	-
EIJ81_RS09955	1669711..1670019	-	309	WP_012550277.1	hypothetical protein	-
EIJ81_RS09960	1670001..1670663	-	663	WP_012550278.1	hypothetical protein	-
EIJ81_RS09965	1670844..1671158	-	315	WP_012550279.1	type II toxin-antitoxin system MqsA family antitoxin	-
EIJ81_RS09970	1671145..1671477	-	333	WP_023603298.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EIJ81_RS09975	1671686..1672135	-	450	WP_044583261.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (83-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-90)

Sequences

Toxin

Protein

• Length: 168 a.a.
• Molecular weight: 19038.00 Da
• Isoelectric Point: 8.4469

>T115583 WP_012550273.1 NZ_CP034240:1667130-1667633 [Aliivibrio salmonicida]
MNTVQLEKAKHDRNRFDCGITALNNYLKVMASQQAKKDNTRTFVLEDKQCPEHIIGYYTLTMTPIDIQDLPPKLQKKHHS
VTSGGLIARLAVDHRYKGQRFGEWLLIDALRKLLMASETVAFPVVIVDVKDGAEYFYEKYGFTAFKDADNKLFITIADIR
ASIGELI

Nucleotide

• Length: 504 bp

>T115583 NZ_CP034240:1667130-1667633 [Aliivibrio salmonicida]
ATGAATACTGTCCAATTAGAAAAAGCTAAACATGACCGAAACCGTTTTGATTGTGGCATTACCGCACTCAATAATTACTT
AAAAGTTATGGCAAGCCAACAAGCTAAGAAAGACAATACTCGTACTTTTGTTCTTGAAGATAAACAATGTCCTGAGCACA
TTATTGGTTATTACACATTAACAATGACACCAATTGATATTCAGGATTTACCTCCTAAATTACAAAAGAAACATCACAGT
GTAACTTCTGGTGGTTTGATTGCTCGCTTAGCCGTTGACCATAGATACAAAGGTCAGAGGTTCGGTGAATGGCTTTTGAT
TGATGCACTTAGAAAGCTATTAATGGCAAGTGAAACAGTCGCCTTCCCTGTTGTCATTGTTGATGTAAAAGATGGCGCTG
AGTATTTCTATGAAAAATACGGATTTACCGCATTCAAAGACGCTGATAACAAACTGTTTATTACAATTGCAGACATTAGA
GCCAGTATCGGTGAATTAATTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9938.46 Da
• Isoelectric Point: 8.6157

>AT115583 WP_044583260.1 NZ_CP034240:1666858-1667133 [Aliivibrio salmonicida]
MATALPRITARVDIDTQELLSQAAAIAGMSSINSFVLSAAVEKAKTIMERERALQLSQQDAMTLMTALDQPAKPNNKLQK
AASRYMDKTQE

Nucleotide

• Length: 276 bp

>AT115583 NZ_CP034240:1666858-1667133 [Aliivibrio salmonicida]
ATGGCTACTGCATTACCCCGTATTACAGCACGTGTAGATATTGATACACAAGAACTACTGTCTCAAGCTGCGGCCATTGC
CGGTATGTCTAGCATTAACTCATTTGTGCTTAGTGCGGCTGTAGAAAAAGCAAAAACTATTATGGAACGTGAACGAGCCC
TACAACTAAGCCAGCAAGATGCTATGACGTTAATGACTGCGTTAGACCAACCAGCTAAACCAAATAACAAATTACAAAAA
GCCGCTTCACGTTATATGGATAAAACTCAAGAATGA

Structures

Toxin

• AlphaFold DB: B6EME0