Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4678058..4678902 Replicon chromosome
Accession NZ_CP034212
Organism Escherichia albertii strain 2010C-3449

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag CCF17_RS23990 Protein ID WP_000854686.1
Coordinates 4678519..4678902 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CCF17_RS23985 Protein ID WP_151402260.1
Coordinates 4678058..4678438 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF17_RS23935 (4673596) 4673596..4674051 + 456 WP_151402258.1 IrmA family protein -
CCF17_RS23945 (4674252) 4674252..4674710 + 459 WP_143354370.1 IS200/IS605-like element IS200C family transposase -
CCF17_RS23950 (4674841) 4674841..4675074 + 234 WP_001119719.1 DUF905 family protein -
CCF17_RS23960 (4675174) 4675174..4675992 + 819 WP_151402259.1 DUF932 domain-containing protein -
CCF17_RS23965 (4676084) 4676084..4676569 + 486 WP_000214307.1 antirestriction protein -
CCF17_RS23970 (4676585) 4676585..4677061 + 477 WP_001747787.1 RadC family protein -
CCF17_RS23975 (4677124) 4677124..4677345 + 222 WP_023277916.1 DUF987 domain-containing protein -
CCF17_RS23980 (4677364) 4677364..4678047 + 684 WP_000086769.1 hypothetical protein -
CCF17_RS23985 (4678058) 4678058..4678438 + 381 WP_151402260.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CCF17_RS23990 (4678519) 4678519..4678902 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
CCF17_RS23995 (4678899) 4678899..4679387 + 489 WP_001054233.1 DUF5983 family protein -
CCF17_RS24000 (4679404) 4679404..4679601 + 198 WP_000839253.1 DUF957 domain-containing protein -
CCF17_RS24005 (4679686) 4679686..4680528 + 843 WP_151402406.1 DUF4942 domain-containing protein -
CCF17_RS24015 (4680999) 4680999..4681937 + 939 WP_000351273.1 glyoxylate/hydroxypyruvate reductase GhrA -
CCF17_RS24020 (4682009) 4682009..4682746 + 738 WP_000283677.1 phosphatase -
CCF17_RS24025 (4682770) 4682770..4683324 + 555 WP_151402261.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4665687..4678902 13215
- flank IS/Tn - - 4674252..4674710 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T115508 WP_000854686.1 NZ_CP034212:4678519-4678902 [Escherichia albertii]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T115508 NZ_CP034212:4678519-4678902 [Escherichia albertii]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13928.65 Da        Isoelectric Point: 5.0823

>AT115508 WP_151402260.1 NZ_CP034212:4678058-4678438 [Escherichia albertii]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPSE

Download         Length: 381 bp

>AT115508 NZ_CP034212:4678058-4678438 [Escherichia albertii]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTTCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References