Detailed information of TA system TA115505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3823198..3823816
• Replicon: chromosome
• Accession: NZ_CP034212
• Organism: Escherichia albertii strain 2010C-3449

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: CCF17_RS19590
• Protein ID: WP_001280991.1
• Coordinates: 3823198..3823416 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: CCF17_RS19595
• Protein ID: WP_151402015.1
• Coordinates: 3823442..3823816 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCF17_RS19555 (3818479)	3818479..3819059	+	581	Protein_3755	YbaY family lipoprotein	-
CCF17_RS19560 (3819089)	3819089..3819400	-	312	WP_000409915.1	MGMT family protein	-
CCF17_RS19570 (3819781)	3819781..3820134	+	354	WP_151402014.1	DUF1428 family protein	-
CCF17_RS19575 (3820172)	3820172..3821722	-	1551	Protein_3758	EAL domain-containing protein	-
CCF17_RS19580 (3821886)	3821886..3822356	-	471	WP_000136188.1	YlaC family protein	-
CCF17_RS19585 (3822464)	3822464..3823021	-	558	WP_000093562.1	maltose O-acetyltransferase	-
CCF17_RS19590 (3823198)	3823198..3823416	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
CCF17_RS19595 (3823442)	3823442..3823816	-	375	WP_151402015.1	Hha toxicity modulator TomB	Antitoxin
CCF17_RS19600 (3824371)	3824371..3827520	-	3150	WP_001132500.1	efflux RND transporter permease AcrB	-
CCF17_RS19605 (3827543)	3827543..3828736	-	1194	WP_010334435.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T115505 WP_001280991.1 NZ_CP034212:c3823416-3823198 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T115505 NZ_CP034212:c3823416-3823198 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14483.40 Da
• Isoelectric Point: 5.1542

>AT115505 WP_151402015.1 NZ_CP034212:c3823816-3823442 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQVLQKWRKSGNRLFRCFVNATKANPASLSC

Nucleotide

• Length: 375 bp

>AT115505 NZ_CP034212:c3823816-3823442 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGTTCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Structures

Toxin

• PDB: 4ICG