Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1886803..1887635 Replicon chromosome
Accession NZ_CP034212
Organism Escherichia albertii strain 2010C-3449

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag CCF17_RS09790 Protein ID WP_000854765.1
Coordinates 1886803..1887177 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A403D757
Locus tag CCF17_RS09795 Protein ID WP_016230789.1
Coordinates 1887267..1887635 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF17_RS25595 (1885867) 1885867..1886016 - 150 Protein_1892 hypothetical protein -
CCF17_RS09780 (1886122) 1886122..1886298 - 177 WP_000839290.1 DUF957 domain-containing protein -
CCF17_RS09785 (1886315) 1886315..1886806 - 492 WP_151401407.1 DUF5983 family protein -
CCF17_RS09790 (1886803) 1886803..1887177 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
CCF17_RS09795 (1887267) 1887267..1887635 - 369 WP_016230789.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CCF17_RS09800 (1887798) 1887798..1888019 - 222 WP_000692345.1 DUF987 domain-containing protein -
CCF17_RS09805 (1888082) 1888082..1888558 - 477 WP_001186774.1 RadC family protein -
CCF17_RS09810 (1888574) 1888574..1889059 - 486 WP_000849588.1 antirestriction protein -
CCF17_RS09815 (1889114) 1889114..1889932 - 819 Protein_1900 DUF932 domain-containing protein -
CCF17_RS09825 (1890032) 1890032..1890265 - 234 WP_001119717.1 DUF905 family protein -
CCF17_RS09830 (1890344) 1890344..1890798 - 455 Protein_1902 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T115495 WP_000854765.1 NZ_CP034212:c1887177-1886803 [Escherichia albertii]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T115495 NZ_CP034212:c1887177-1886803 [Escherichia albertii]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.45 Da        Isoelectric Point: 7.0264

>AT115495 WP_016230789.1 NZ_CP034212:c1887635-1887267 [Escherichia albertii]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT115495 NZ_CP034212:c1887635-1887267 [Escherichia albertii]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A403D757

References