Detailed information of TA system TA115409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 3897450..3898250
• Replicon: chromosome
• Accession: NZ_CP034162
• Organism: Escherichia albertii strain 06-3542

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: CCS91_RS19330
• Protein ID: WP_059220924.1
• Coordinates: 3897723..3898250 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: B1EHP0
• Locus tag: CCS91_RS19325
• Protein ID: WP_001277106.1
• Coordinates: 3897450..3897716 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCS91_RS19305	3893106..3893774	+	669	WP_000617720.1	cell division ATP-binding protein FtsE	-
CCS91_RS19310	3893767..3894825	+	1059	WP_001042000.1	permease-like cell division protein FtsX	-
CCS91_RS19315	3895070..3895924	+	855	WP_000130217.1	RNA polymerase sigma factor RpoH	-
CCS91_RS19320	3896197..3897300	+	1104	WP_124866574.1	branched chain amino acid ABC transporter substrate-binding protein LivJ	-
CCS91_RS19325	3897450..3897716	+	267	WP_001277106.1	DUF1778 domain-containing protein	Antitoxin
CCS91_RS19330	3897723..3898250	+	528	WP_059220924.1	GNAT family N-acetyltransferase	Toxin
CCS91_RS19335	3898247..3898630	-	384	WP_059220922.1	aspartate 1-decarboxylase autocleavage activator PanM	-
CCS91_RS19340	3899054..3900163	+	1110	WP_059220920.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
CCS91_RS19345	3900211..3901137	+	927	WP_001295111.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
CCS91_RS19350	3901134..3902411	+	1278	WP_059275495.1	branched chain amino acid ABC transporter permease LivM	-
CCS91_RS19355	3902408..3903175	+	768	WP_124866576.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (90-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19490.38 Da
• Isoelectric Point: 6.6303

>T115409 WP_059220924.1 NZ_CP034162:3897723-3898250 [Escherichia albertii]
MDDLTIEILTDDADYDLQRLDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVCSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Nucleotide

• Length: 528 bp

>T115409 NZ_CP034162:3897723-3898250 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTAGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGCTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9942.37 Da
• Isoelectric Point: 10.0863

>AT115409 WP_001277106.1 NZ_CP034162:3897450-3897716 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Nucleotide

• Length: 267 bp

>AT115409 NZ_CP034162:3897450-3897716 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z8E004