Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1259392..1259954 Replicon chromosome
Accession NZ_CP034162
Organism Escherichia albertii strain 06-3542

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CCS91_RS06385 Protein ID WP_059276333.1
Coordinates 1259392..1259670 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag CCS91_RS06390 Protein ID WP_000781370.1
Coordinates 1259670..1259954 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCS91_RS06365 1255381..1255812 - 432 WP_000152289.1 peroxiredoxin OsmC -
CCS91_RS06370 1256070..1256207 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
CCS91_RS06375 1256364..1258061 + 1698 WP_000433442.1 malate dehydrogenase -
CCS91_RS06380 1258196..1259206 + 1011 WP_124866148.1 alcohol dehydrogenase AdhP -
CCS91_RS06385 1259392..1259670 + 279 WP_059276333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCS91_RS06390 1259670..1259954 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
CCS91_RS06395 1260183..1260836 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
CCS91_RS06400 1260829..1261713 - 885 WP_059268408.1 formate dehydrogenase N subunit beta -
CCS91_RS06405 1261726..1264773 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10481.08 Da        Isoelectric Point: 7.2751

>T115398 WP_059276333.1 NZ_CP034162:1259392-1259670 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLPPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T115398 NZ_CP034162:1259392-1259670 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGTTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
CCCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT115398 WP_000781370.1 NZ_CP034162:1259670-1259954 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT115398 NZ_CP034162:1259670-1259954 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACACCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References