Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 244353..245017 Replicon chromosome
Accession NZ_CP034118
Organism Staphylospora marina strain SCSIO 07575

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag EG886_RS01365 Protein ID WP_124726468.1
Coordinates 244667..245017 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EG886_RS01360 Protein ID WP_124726467.1
Coordinates 244353..244661 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EG886_RS01340 239764..241314 + 1551 WP_124726464.1 NAD(P)H-hydrate dehydratase -
EG886_RS01345 241353..242378 + 1026 WP_124726465.1 outer membrane lipoprotein-sorting protein -
EG886_RS01350 242534..242965 + 432 WP_124726466.1 hypothetical protein -
EG886_RS01355 242958..244160 + 1203 WP_124728609.1 alanine racemase -
EG886_RS01360 244353..244661 + 309 WP_124726467.1 ribbon-helix-helix protein, CopG family Antitoxin
EG886_RS01365 244667..245017 + 351 WP_124726468.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EG886_RS01370 245172..246182 + 1011 WP_124726469.1 PP2C family protein-serine/threonine phosphatase -
EG886_RS01375 246225..246560 + 336 WP_124726470.1 STAS domain-containing protein -
EG886_RS01380 246557..247042 + 486 WP_124726471.1 anti-sigma B factor RsbW -
EG886_RS01385 247005..247790 + 786 WP_124726472.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(18-54)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12966.03 Da        Isoelectric Point: 5.1342

>T115293 WP_124726468.1 NZ_CP034118:244667-245017 [Staphylospora marina]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMNRVNEALMISLGIIDF

Download         Length: 351 bp

>T115293 NZ_CP034118:244667-245017 [Staphylospora marina]
TTGATAGTCAAACGTGGCGATGTGTATTTTGCAGATCTCTCCCCCGTGGTCGGATCCGAACAAGGTGGGGTTCGGCCCGT
CTTGGTCATTCAAAACGATATTGGGAACCGGTTCAGCCCCACCGTCATCGTCGCCGCGATTACCGCCCAGATTCAAAAGG
CCAAGTTGCCCACCCATGTGGAGATCGACGCCAAGACGTACGGTTTTGACAGGGATTCCGTCATCTTGCTGGAACAGATC
CGGACGATTGACAAGCAACGCTTGACCGACAAGATCACGCATCTGGATGAGGAAATGATGAACCGGGTCAATGAAGCCCT
GATGATCAGTTTGGGCATCATCGATTTCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11794.70 Da        Isoelectric Point: 5.9007

>AT115293 WP_124726467.1 NZ_CP034118:244353-244661 [Staphylospora marina]
MHNGDDWLGVLQLSGTKRIMISLPTNLLQEVDGIVARENLSRSEIIRRAMKMYVQERKKRIIREMMQRGYMEMARINLNI
ASEAFALEEEAEDTLDRLVSGV

Download         Length: 309 bp

>AT115293 NZ_CP034118:244353-244661 [Staphylospora marina]
ATGCATAACGGTGATGATTGGTTGGGGGTGCTTCAGTTGTCCGGTACCAAGCGAATCATGATCAGCCTGCCAACGAATCT
GCTTCAGGAAGTGGACGGGATCGTTGCCCGGGAGAATCTGAGCCGCAGCGAAATCATCCGCCGAGCGATGAAGATGTATG
TGCAGGAACGAAAGAAACGCATCATTCGCGAAATGATGCAACGAGGATACATGGAAATGGCCAGGATCAACCTCAACATC
GCTTCCGAAGCGTTCGCGCTGGAAGAAGAGGCTGAAGACACTTTGGACCGTTTGGTTAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References