115286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1475079..1475588 Replicon chromosome
Accession NZ_CP034111
Organism Staphylococcus epidermidis strain CDC120

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag EH162_RS07430 Protein ID WP_001829980.1
Coordinates 1475379..1475588 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag EH162_RS07425 Protein ID WP_001829893.1
Coordinates 1475079..1475372 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH162_RS07400 1470087..1470875 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
EH162_RS07405 1470881..1471519 + 639 WP_002505076.1 thiamine phosphate synthase -
EH162_RS07410 1471608..1472480 + 873 WP_002458703.1 membrane protein insertase YidC -
EH162_RS07415 1472586..1473239 - 654 WP_001829983.1 HD domain-containing protein -
EH162_RS07420 1473421..1474905 - 1485 WP_002457116.1 cardiolipin synthase -
EH162_RS07425 1475079..1475372 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
EH162_RS07430 1475379..1475588 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
EH162_RS07435 1475731..1475868 + 138 WP_001829949.1 hypothetical protein -
EH162_RS07440 1475968..1477179 - 1212 WP_001829910.1 rod shape-determining protein RodA -
EH162_RS07445 1477570..1478643 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
EH162_RS07450 1478655..1480010 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T115286 WP_001829980.1 NZ_CP034111:1475379-1475588 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T115286 NZ_CP034111:1475379-1475588 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT115286 WP_001829893.1 NZ_CP034111:1475079-1475372 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT115286 NZ_CP034111:1475079-1475372 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References