Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 886954..887474 Replicon chromosome
Accession NZ_CP034089
Organism Bifidobacterium longum strain LTBL16

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4V2N101
Locus tag EH079_RS03900 Protein ID WP_065436690.1
Coordinates 886954..887208 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A4R0SSB9
Locus tag EH079_RS03905 Protein ID WP_065436689.1
Coordinates 887208..887474 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EH079_RS03875 882622..884298 - 1677 WP_077385842.1 ATP-binding protein -
EH079_RS03880 884387..884632 - 246 WP_007053507.1 hypothetical protein -
EH079_RS03885 884904..885422 + 519 WP_065436692.1 hypothetical protein -
EH079_RS03890 885433..885813 + 381 WP_155661339.1 hypothetical protein -
EH079_RS03895 885897..886960 + 1064 Protein_742 hypothetical protein -
EH079_RS03900 886954..887208 - 255 WP_065436690.1 Txe/YoeB family addiction module toxin Toxin
EH079_RS03905 887208..887474 - 267 WP_065436689.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EH079_RS03910 887659..888039 + 381 WP_065436688.1 hypothetical protein -
EH079_RS03915 888062..888484 + 423 WP_065436687.1 hypothetical protein -
EH079_RS03920 888548..888910 + 363 WP_007057233.1 hypothetical protein -
EH079_RS03925 888926..889438 - 513 WP_101025942.1 hypothetical protein -
EH079_RS03930 889709..890026 - 318 WP_032737827.1 HigA family addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 834843..926938 92095


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-76)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9932.40 Da        Isoelectric Point: 8.4862

>T115192 WP_065436690.1 NZ_CP034089:c887208-886954 [Bifidobacterium longum]
MLLCWTEDAWADYLYWQAQDRKTLKRVNTLIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCILSA
KDHY

Download         Length: 255 bp

>T115192 NZ_CP034089:c887208-886954 [Bifidobacterium longum]
ATGCTGCTCTGCTGGACCGAAGACGCCTGGGCCGACTACCTGTACTGGCAGGCTCAGGACCGCAAGACCCTCAAGCGCGT
CAACACGCTCATCCGGGACATGCAGCGGACCCCGTTCGAAGGCATCGGCAAGCCCGAACCCCTCAAATGGGGCCTGTCCG
GCGCATGGTCGCGACGTATCGATTCGGCCAACCGTATCATCTATACCGTCGCCGACGACAGGCTCTGCATCCTCTCCGCG
AAGGACCACTACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9908.15 Da        Isoelectric Point: 4.3407

>AT115192 WP_065436689.1 NZ_CP034089:c887474-887208 [Bifidobacterium longum]
MTQAVAYSNFRANLKTYMRKVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQTMA
HDLIEAGA

Download         Length: 267 bp

>AT115192 NZ_CP034089:c887474-887208 [Bifidobacterium longum]
ATGACACAGGCCGTGGCCTACAGCAATTTCAGGGCGAATCTCAAGACCTATATGCGCAAGGTCAACGAGGACGCCGACAC
CCTTCTCGTGACCAACGCGGACCCGGAGGACAACGTGGTCGTGATGAGCGCCGACGACTACGATTCGCTCATGGAGACGC
TGCGCGTCTACCAGAACCCGTATCTGAGCGACAAGGTGATGCGCGGCATGGCGCAGGTCCGGCAGGGCCAGACGATGGCC
CACGACCTTATCGAAGCGGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V2N101

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0SSB9

References