Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2716755..2717425 Replicon chromosome
Accession NZ_CP034086
Organism Methylocystis rosea strain GW6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EHO51_RS13165 Protein ID WP_124739262.1
Coordinates 2716755..2717165 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EHO51_RS13170 Protein ID WP_124739263.1
Coordinates 2717174..2717425 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHO51_RS13135 2712519..2712746 - 228 WP_018406116.1 zinc ribbon domain-containing protein -
EHO51_RS13140 2712961..2713911 - 951 WP_192879556.1 cobaltochelatase subunit CobS -
EHO51_RS13145 2714054..2714653 - 600 WP_124739260.1 J domain-containing protein -
EHO51_RS13150 2714740..2715036 + 297 WP_026222596.1 BolA family transcriptional regulator -
EHO51_RS13155 2715042..2715356 - 315 WP_124740155.1 hypothetical protein -
EHO51_RS13160 2715551..2716732 + 1182 WP_124739261.1 phosphoserine transaminase -
EHO51_RS13165 2716755..2717165 - 411 WP_124739262.1 type II toxin-antitoxin system VapC family toxin Toxin
EHO51_RS13170 2717174..2717425 - 252 WP_124739263.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EHO51_RS13175 2717594..2719180 + 1587 WP_124739264.1 phosphoglycerate dehydrogenase -
EHO51_RS13180 2719359..2719982 + 624 WP_124739265.1 L,D-transpeptidase -
EHO51_RS13185 2720059..2720433 - 375 WP_124739266.1 DUF971 domain-containing protein -
EHO51_RS13190 2720539..2722404 - 1866 WP_124739267.1 extracellular solute-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-126)

Antitoxin

SpoVT-AbrB domain

(8-46)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15100.26 Da        Isoelectric Point: 7.2781

>T115189 WP_124739262.1 NZ_CP034086:c2717165-2716755 [Methylocystis rosea]
MFCLDTNVIIGVMTRRAPHLDERLRAELLYGSRLLVPAPVLSELRYGAAKSVAPERNHARLDDFLSAISEIATFDADDAR
AAGDIRAYLEGHGKPIGPYDVLIAAQARRRGAVLVTANRREFDRVPGLMVTDWNDR

Download         Length: 411 bp

>T115189 NZ_CP034086:c2717165-2716755 [Methylocystis rosea]
ATGTTTTGTCTCGATACGAATGTGATCATAGGCGTAATGACTCGGCGCGCGCCTCACCTCGACGAGCGGCTGAGAGCTGA
GCTGCTTTACGGATCGCGCTTGCTCGTCCCCGCGCCGGTCCTTTCCGAGCTTCGCTACGGCGCAGCGAAAAGCGTGGCGC
CCGAGAGGAATCATGCGCGACTCGACGACTTCCTCTCGGCCATATCCGAAATCGCGACTTTCGACGCTGATGACGCGCGC
GCCGCAGGCGACATTCGCGCTTATCTTGAAGGTCATGGAAAACCGATCGGCCCTTATGACGTTTTGATCGCCGCACAGGC
GCGCCGGCGCGGCGCCGTTCTCGTCACCGCTAACCGCCGCGAGTTCGACCGCGTGCCGGGCCTGATGGTGACGGACTGGA
ACGATCGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9437.79 Da        Isoelectric Point: 4.5370

>AT115189 WP_124739263.1 NZ_CP034086:c2717425-2717174 [Methylocystis rosea]
MTATAKLFKHGRSQAVRLPKEFRMPGSEVRVSKVGDKIILEPLEKPPFDVEAWRAKLDTYLDVDFPEVPAEPPLEPDDEV
TFD

Download         Length: 252 bp

>AT115189 NZ_CP034086:c2717425-2717174 [Methylocystis rosea]
ATGACCGCCACCGCGAAATTATTCAAGCATGGCCGCAGCCAAGCCGTTCGGCTTCCCAAGGAATTTCGGATGCCGGGCTC
CGAGGTGCGCGTCAGCAAAGTCGGCGACAAGATCATTTTGGAGCCGTTGGAAAAGCCGCCCTTCGACGTCGAGGCGTGGC
GTGCAAAGCTCGACACCTATCTCGACGTGGACTTTCCGGAGGTCCCGGCCGAACCTCCGCTCGAACCCGATGACGAAGTC
ACTTTCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References