Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4292675..4293298 Replicon chromosome
Accession NZ_CP034078
Organism Pseudomonas syringae pv. pisi str. PP1

Toxin (Protein)


Gene name hicA Uniprot ID A0A3M3C685
Locus tag N032_RS19720 Protein ID WP_003314536.1
Coordinates 4293116..4293298 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3M3C5W4
Locus tag N032_RS19715 Protein ID WP_010421644.1
Coordinates 4292675..4293079 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N032_RS19700 4288441..4289109 + 669 WP_024648672.1 ABC transporter ATP-binding protein -
N032_RS19705 4289109..4291589 + 2481 WP_024648671.1 ABC transporter permease -
N032_RS19710 4291579..4292658 + 1080 WP_024648670.1 iron ABC transporter permease -
N032_RS19715 4292675..4293079 - 405 WP_010421644.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N032_RS19720 4293116..4293298 - 183 WP_003314536.1 type II toxin-antitoxin system HicA family toxin Toxin
N032_RS19725 4293582..4295354 + 1773 WP_004416697.1 N-acetylglutaminylglutamine amidotransferase -
N032_RS19730 4295358..4297106 + 1749 WP_003418255.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6763.96 Da        Isoelectric Point: 10.6643

>T115153 WP_003314536.1 NZ_CP034078:c4293298-4293116 [Pseudomonas syringae pv. pisi str. PP1]
VQSRQLIKELEADGWVLDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

>T115153 NZ_CP034078:c4293298-4293116 [Pseudomonas syringae pv. pisi str. PP1]
GTGCAAAGCAGGCAATTGATAAAGGAGCTTGAAGCTGATGGATGGGTTCTTGATCGTGTTTCGGGCAGTCACCATATGTT
CAAGCATCCTGAAAAGCTTCAGACAGTCCCCGTGCCGCATCCCAAGAAAGACTTGCCATTCGGAACGGTGCGGGCCATCA
AAAAGCTTGCCGGGCTGGTTTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14568.66 Da        Isoelectric Point: 5.5960

>AT115153 WP_010421644.1 NZ_CP034078:c4293079-4292675 [Pseudomonas syringae pv. pisi str. PP1]
MKYPMCIEWGNETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAASGRTIPKAGNVAEHARNPDFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT115153 NZ_CP034078:c4293079-4292675 [Pseudomonas syringae pv. pisi str. PP1]
ATGAAATACCCAATGTGCATAGAATGGGGAAACGAGACCACGGCGTTTGGTATCCAGATTCCCGATATTCCCGGTGCCGT
AACAGCTGGCGATACGTTCGAGGAAGCCCACGCTGCGGCGGTTGAGATTGCTCATATCATGCTGCAGGAGATAGCAGCCA
GCGGTAGAACCATACCCAAGGCCGGAAACGTTGCCGAGCACGCCAGGAATCCCGATTTCGCAGGGATGGGCTGGGGCATG
ATCGAGATTGACGTAACGCCTTATCTCGGCAAGACGGAGAAGGTCAACGTCACACTGCCTGGTTTCGTGATCAGGCAGAT
TGATCGCTATGTGCGGGATCACAGCATCAAGAGCCGCTCGACCTTTCTGGCCGACGCGGCGCTGGAAAAACTGGGTCGAG
CATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3C685

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3C5W4

References