Detailed information of TA system TA114557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 3625903..3626438
• Replicon: chromosome
• Accession: NZ_CP033875
• Organism: Caulobacter sp. FWC26

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CSW63_RS18815
• Protein ID: WP_082749801.1
• Coordinates: 3626151..3626438 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A3S9VIU4
• Locus tag: CSW63_RS18810
• Protein ID: WP_062099815.1
• Coordinates: 3625903..3626154 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSW63_RS18780	3621185..3621940	-	756	WP_062099811.1	M48 family metallopeptidase	-
CSW63_RS18785	3622021..3622362	-	342	WP_082749813.1	response regulator	-
CSW63_RS18790	3622373..3623413	-	1041	WP_062099812.1	PAS domain S-box protein	-
CSW63_RS18795	3623575..3624675	-	1101	WP_062099813.1	DUF4167 domain-containing protein	-
CSW63_RS18800	3624672..3624896	-	225	Protein_3355	hypothetical protein	-
CSW63_RS18805	3624934..3625803	-	870	WP_062099814.1	peptide chain release factor N(5)-glutamine methyltransferase	-
CSW63_RS18810	3625903..3626154	+	252	WP_062099815.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CSW63_RS18815	3626151..3626438	+	288	WP_082749801.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CSW63_RS18820	3626439..3627200	-	762	WP_099503091.1	MOSC domain-containing protein	-
CSW63_RS18825	3627303..3628520	+	1218	WP_099503089.1	YihY/virulence factor BrkB family protein	-
CSW63_RS18830	3628610..3629137	+	528	WP_062099819.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10920.48 Da
• Isoelectric Point: 8.8651

>T114557 WP_082749801.1 NZ_CP033875:3626151-3626438 [Caulobacter sp. FWC26]
VSAYRLTPRARYDVREIWAYTIGVWGRRAADRYIRELTKTFEAIASDPSLGAVVEGLDCRKQIFRSHVIYYAPENDAVIV
VRVLHQQMDAPSHLT

Nucleotide

• Length: 288 bp

>T114557 NZ_CP033875:3626151-3626438 [Caulobacter sp. FWC26]
GTGAGCGCGTATCGCCTGACGCCTCGCGCACGATACGACGTGCGAGAAATCTGGGCCTATACCATCGGCGTGTGGGGGCG
TCGGGCCGCAGACCGATACATCCGCGAGCTAACCAAGACGTTCGAAGCGATCGCCAGCGATCCAAGCCTCGGCGCGGTCG
TGGAAGGCTTGGATTGCCGCAAGCAGATCTTTCGCTCCCACGTAATCTACTACGCGCCCGAGAATGACGCGGTCATCGTG
GTGCGCGTGCTGCATCAGCAGATGGACGCGCCAAGCCACCTGACCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9048.02 Da
• Isoelectric Point: 4.4621

>AT114557 WP_062099815.1 NZ_CP033875:3625903-3626154 [Caulobacter sp. FWC26]
MSKNTSIVLSEHFQSFIAEQIGEGRYGSASEVVRAGLRLLENQEAKLAALRNALKEGWDSGKPEAFDVEAFLAEANADYD
AKS

Nucleotide

• Length: 252 bp

>AT114557 NZ_CP033875:3625903-3626154 [Caulobacter sp. FWC26]
ATGAGCAAGAATACGTCCATCGTGCTCAGCGAGCACTTTCAGTCTTTCATCGCCGAACAGATCGGGGAAGGCCGCTATGG
CTCGGCCAGCGAGGTCGTCCGCGCCGGGCTCCGGTTGCTGGAAAATCAGGAAGCCAAACTCGCGGCGCTGCGAAACGCCC
TGAAGGAGGGCTGGGACAGCGGCAAGCCTGAGGCCTTCGACGTTGAGGCCTTTCTGGCTGAGGCGAACGCCGACTACGAC
GCGAAATCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3S9VIU4