Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1816905..1818155 Replicon chromosome
Accession NZ_CP033838
Organism Burkholderia dolosa strain FDAARGOS_562

Toxin (Protein)


Gene name vapC Uniprot ID A0A892IA44
Locus tag EGY28_RS08125 Protein ID WP_006766297.1
Coordinates 1816905..1817504 (-) Length 200 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A892I3E7
Locus tag EGY28_RS08130 Protein ID WP_035974448.1
Coordinates 1817598..1818155 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY28_RS08100 1811927..1812724 + 798 WP_035974452.1 enoyl-CoA hydratase -
EGY28_RS08105 1812721..1813860 + 1140 WP_006766300.1 enoyl-CoA hydratase/isomerase family protein -
EGY28_RS08110 1813947..1814852 - 906 WP_035974451.1 LysR family transcriptional regulator -
EGY28_RS08115 1815025..1816563 + 1539 WP_006766298.1 MFS transporter -
EGY28_RS08125 1816905..1817504 - 600 WP_006766297.1 HD domain-containing protein Toxin
EGY28_RS08130 1817598..1818155 - 558 WP_035974448.1 helix-turn-helix domain-containing protein Antitoxin
EGY28_RS08135 1818500..1819903 + 1404 WP_006766295.1 hypothetical protein -
EGY28_RS08140 1820019..1821277 + 1259 Protein_1574 IS256 family transposase -
EGY28_RS08145 1821267..1821497 + 231 WP_105773928.1 integrase core domain-containing protein -
EGY28_RS08150 1821775..1821987 - 213 WP_105773927.1 transposase -
EGY28_RS08155 1822278..1822775 + 498 WP_123806756.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-49)


Sequences

Toxin        


Download         Length: 200 a.a.        Molecular weight: 21892.64 Da        Isoelectric Point: 5.1098

>T114457 WP_006766297.1 NZ_CP033838:c1817504-1816905 [Burkholderia dolosa]
MTPDTIHARLDFLREAERLKDVLRSGRTSSGRAESTAEHSWRLCLMALAFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERNDLLTLTAALDGPLRDEIVALWDEYEAVATPEARAAKALDKLETILQHNQGDNPPDFDYAFNLDY
GRRYTDAAPLFIAIRAVVDADTQRRIDARAHTACTKGSA

Download         Length: 600 bp

>T114457 NZ_CP033838:c1817504-1816905 [Burkholderia dolosa]
ATGACTCCCGACACGATTCACGCACGACTGGATTTTCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGAGCGGACGCGCCGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTGGCGTTCGCCGACGCGC
TGCCCGGCGTCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTGCACGATCTCGGCGAGGCGCTGCACGGCGACATTCCG
GCGATCGAGCAAGCCGCGCATCCGGACAAGAGCGCGCACGAGCGCAACGATCTGCTGACGCTGACGGCGGCGCTCGACGG
CCCGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATATGAAGCGGTCGCGACGCCGGAAGCCCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCGACAACCCGCCCGATTTCGATTACGCGTTCAATCTCGACTAT
GGCCGGCGCTACACGGATGCGGCGCCGCTGTTCATCGCGATCCGCGCGGTCGTCGATGCGGACACGCAACGCAGAATCGA
CGCACGCGCGCACACCGCTTGCACGAAGGGTTCCGCATGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20283.30 Da        Isoelectric Point: 8.8096

>AT114457 WP_035974448.1 NZ_CP033838:c1818155-1817598 [Burkholderia dolosa]
MAAPALHTPPLGPQLKRWRVLHRIKQSHAAELFGVAQSTISRWEAGIQQMSADERATAERLLAAHLDSAGDHALARLIAD
SAGRMHLVCDLTHRLLACSPLRAAEFSQPLPLLLGTSLWRYATPEIVRMESALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAVRLVETL

Download         Length: 558 bp

>AT114457 NZ_CP033838:c1818155-1817598 [Burkholderia dolosa]
ATGGCAGCGCCCGCACTTCATACGCCACCGCTGGGCCCGCAACTGAAGCGCTGGCGCGTGCTGCACCGGATAAAGCAGAG
CCACGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCCGCCGACG
AGCGCGCGACGGCGGAACGTCTGCTCGCCGCGCATCTCGATTCCGCCGGCGACCATGCACTCGCGCGGCTGATCGCGGAC
AGCGCGGGCCGCATGCATCTGGTGTGCGACCTCACGCATCGTCTGCTCGCGTGCTCGCCGCTGCGTGCGGCCGAGTTCTC
GCAGCCGCTGCCGCTGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACGCCGGAGATCGTCCGCATGGAATCGGCGCTCG
ACACGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCAAACGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCCGATGCCGCTGGACGCGGATGACGCTGTCGGACGGATCGGCGGTGCGTCTGGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References