Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 1080793..1081234 Replicon chromosome
Accession NZ_CP033787
Organism Enterococcus faecalis strain FDAARGOS_528

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag EGX75_RS05495 Protein ID WP_002396786.1
Coordinates 1080793..1080936 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 1081033..1081234 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX75_RS05490 1075928..1080598 + 4671 WP_123839673.1 WxL domain-containing protein -
EGX75_RS05495 1080793..1080936 - 144 WP_002396786.1 putative holin-like toxin Toxin
- 1081033..1081234 + 202 - - Antitoxin
EGX75_RS05500 1081167..1081307 - 141 WP_077143780.1 putative holin-like toxin -
EGX75_RS05505 1081426..1081623 - 198 WP_002358966.1 putative holin-like toxin -
EGX75_RS05510 1081809..1081931 - 123 WP_002404776.1 putative holin-like toxin -
EGX75_RS05515 1082286..1083902 - 1617 WP_123839674.1 phosphatase PAP2/LCP family protein -
EGX75_RS05530 1084364..1085659 + 1296 WP_002396787.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T114345 WP_002396786.1 NZ_CP033787:c1080936-1080793 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T114345 NZ_CP033787:c1080936-1080793 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 202 bp

>AT114345 NZ_CP033787:1081033-1081234 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References