Detailed information of TA system TA114106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 58484..59018
• Replicon: plasmid unnamed
• Accession: NZ_CP033710
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_582

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q663N8
• Locus tag: EGX44_RS00410
• Protein ID: WP_002213360.1
• Coordinates: 58484..58783 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: EGX44_RS00415
• Protein ID: WP_012414146.1
• Coordinates: 58776..59018 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX44_RS00380	54111..54536	-	426	WP_002213267.1	type III secretion system chaperone SycH	-
EGX44_RS00385	54914..55312	-	399	Protein_70	ATP-binding protein	-
EGX44_RS00390	55312..56484	-	1173	WP_011191364.1	IS21 family transposase	-
EGX44_RS00395	56587..57036	+	450	Protein_72	transposase family protein	-
EGX44_RS00400	57099..57491	-	393	WP_002213403.1	type III secretion system chaperone SycE/YerA	-
EGX44_RS00405	57685..58344	+	660	WP_002229754.1	type III secretion system effector GTPase activator YopE	-
EGX44_RS00410	58484..58783	-	300	WP_002213360.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGX44_RS00415	58776..59018	-	243	WP_012414146.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EGX44_RS00420	59133..59476	-	344	Protein_77	IS6 family transposase	-
EGX44_RS22675	59561..59734	+	174	WP_002213357.1	hypothetical protein	-
EGX44_RS22680	59883..60299	-	417	WP_155759211.1	hypothetical protein	-
EGX44_RS00430	60459..61424	-	966	WP_002213354.1	ParB/RepB/Spo0J family plasmid partition protein	-
EGX44_RS00435	61421..62587	-	1167	WP_002220902.1	plasmid-partitioning protein SopA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP / yopO/ypkA / yadA / sycH / sycE/yerA / yopE / yopK/yopQ / yopT / sycT	1..69815	69815

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11632.19 Da
• Isoelectric Point: 5.5114

>T114106 WP_002213360.1 NZ_CP033710:c58783-58484 [Yersinia pseudotuberculosis]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Nucleotide

• Length: 300 bp

>T114106 NZ_CP033710:c58783-58484 [Yersinia pseudotuberculosis]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8807.12 Da
• Isoelectric Point: 6.8783

>AT114106 WP_012414146.1 NZ_CP033710:c59018-58776 [Yersinia pseudotuberculosis]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKGTSV

Nucleotide

• Length: 243 bp

>AT114106 NZ_CP033710:c59018-58776 [Yersinia pseudotuberculosis]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGGTACTAGTGTA
TAA

Structures

Toxin

• AlphaFold DB: Q663N8