Detailed information of TA system TA114097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 3889419..3890065
• Replicon: chromosome
• Accession: NZ_CP033709
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_583

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A3G5L3F2
• Locus tag: EGX39_RS18375
• Protein ID: WP_002214976.1
• Coordinates: 3889419..3889601 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0U1R391
• Locus tag: EGX39_RS18380
• Protein ID: WP_002211129.1
• Coordinates: 3889646..3890065 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX39_RS18340	3884745..3885215	+	471	WP_002227961.1	flagellar basal body-associated protein FliL	-
EGX39_RS18345	3885221..3886222	+	1002	WP_011192177.1	flagellar motor switch protein FliM	-
EGX39_RS18350	3886219..3886635	+	417	WP_011192176.1	flagellar motor switch protein FliN	-
EGX39_RS18355	3886635..3887231	+	597	WP_071880005.1	flagellar biosynthetic protein FliO	-
EGX39_RS18360	3887312..3888052	+	741	WP_002220494.1	flagellar type III secretion system pore protein FliP	-
EGX39_RS18365	3888158..3888427	+	270	WP_002211131.1	flagellar biosynthesis protein FliQ	-
EGX39_RS18370	3888430..3889212	+	783	WP_002211130.1	flagellar type III secretion system protein FliR	-
EGX39_RS18375	3889419..3889601	+	183	WP_002214976.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGX39_RS18380	3889646..3890065	+	420	WP_002211129.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EGX39_RS18385	3890323..3891282	-	960	WP_011192172.1	sugar kinase	-
EGX39_RS18390	3891331..3892353	-	1023	WP_011192171.1	ABC transporter permease	-
EGX39_RS18395	3892356..3893933	-	1578	WP_011192170.1	sugar ABC transporter ATP-binding protein	-
EGX39_RS18400	3893999..3894994	-	996	WP_002211125.1	substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-131)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6783.99 Da
• Isoelectric Point: 10.8877

>T114097 WP_002214976.1 NZ_CP033709:3889419-3889601 [Yersinia pseudotuberculosis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Nucleotide

• Length: 183 bp

>T114097 NZ_CP033709:3889419-3889601 [Yersinia pseudotuberculosis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15549.42 Da
• Isoelectric Point: 4.7731

>AT114097 WP_002211129.1 NZ_CP033709:3889646-3890065 [Yersinia pseudotuberculosis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Nucleotide

• Length: 420 bp

>AT114097 NZ_CP033709:3889646-3890065 [Yersinia pseudotuberculosis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Structures

Toxin

• AlphaFold DB: A0A3G5L3F2

Antitoxin

• AlphaFold DB: A0A0U1R391