Detailed information of TA system TA114096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3385770..3386753
• Replicon: chromosome
• Accession: NZ_CP033709
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_583

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: EGX39_RS16015
• Protein ID: WP_011192520.1
• Coordinates: 3385770..3386228 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: EGX39_RS16020
• Protein ID: WP_002210982.1
• Coordinates: 3386307..3386753 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX39_RS15985	3381584..3382249	+	666	WP_011192521.1	phage shock protein PspA	-
EGX39_RS15990	3382411..3382638	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
EGX39_RS15995	3382638..3382997	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
EGX39_RS16000	3383082..3383324	+	243	WP_002216375.1	phage shock protein PspD	-
EGX39_RS16005	3383305..3384702	+	1398	WP_123772550.1	YcjX family protein	-
EGX39_RS16010	3384699..3385760	+	1062	WP_002210980.1	YcjF family protein	-
EGX39_RS16015	3385770..3386228	-	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
EGX39_RS16020	3386307..3386753	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
EGX39_RS16025	3387090..3388667	+	1578	WP_011192519.1	transcriptional regulator TyrR	-
EGX39_RS16030	3388828..3389331	-	504	WP_002210984.1	thiol peroxidase	-
EGX39_RS16035	3389494..3390468	+	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
EGX39_RS16040	3390510..3391217	-	708	WP_002220315.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T114096 WP_011192520.1 NZ_CP033709:c3386228-3385770 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T114096 NZ_CP033709:c3386228-3385770 [Yersinia pseudotuberculosis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT114096 WP_002210982.1 NZ_CP033709:c3386753-3386307 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT114096 NZ_CP033709:c3386753-3386307 [Yersinia pseudotuberculosis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCTAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1