Detailed information of TA system TA114095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2379722..2380416
• Replicon: chromosome
• Accession: NZ_CP033709
• Organism: Yersinia pseudotuberculosis strain FDAARGOS_583

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: EGX39_RS11350
• Protein ID: WP_024063131.1
• Coordinates: 2379722..2380018 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: EGX39_RS11355
• Protein ID: WP_002209924.1
• Coordinates: 2380018..2380416 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX39_RS11320	2374844..2376361	+	1518	WP_002209930.1	lysine--tRNA ligase	-
EGX39_RS11330	2376794..2378008	+	1215	WP_032465901.1	tyrosine-type recombinase/integrase	-
EGX39_RS11335	2378090..2378275	-	186	WP_002209928.1	hypothetical protein	-
EGX39_RS11340	2378873..2379133	+	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EGX39_RS11345	2379196..2379558	+	363	WP_011192920.1	helix-turn-helix domain-containing protein	-
EGX39_RS11350	2379722..2380018	+	297	WP_024063131.1	type II toxin-antitoxin system MqsR family toxin	Toxin
EGX39_RS11355	2380018..2380416	+	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
EGX39_RS11360	2380816..2381337	-	522	WP_072083342.1	potassium-transporting ATPase subunit A	-
EGX39_RS11365	2381457..2383106	-	1650	WP_072083336.1	toprim domain-containing protein	-
EGX39_RS11370	2383406..2383732	+	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EGX39_RS21510	2383725..2383877	+	153	WP_002209921.1	hypothetical protein	-
EGX39_RS11375	2383891..2384091	-	201	WP_002209920.1	AlpA family transcriptional regulator	-
EGX39_RS21515	2384273..2384605	-	333	WP_032466587.1	hypothetical protein	-
EGX39_RS21520	2384720..2384953	-	234	Protein_1989	hypothetical protein	-
EGX39_RS11385	2384966..2385331	-	366	WP_002209919.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11318.17 Da
• Isoelectric Point: 7.8810

>T114095 WP_024063131.1 NZ_CP033709:2379722-2380018 [Yersinia pseudotuberculosis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEI

Nucleotide

• Length: 297 bp

>T114095 NZ_CP033709:2379722-2380018 [Yersinia pseudotuberculosis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT114095 WP_002209924.1 NZ_CP033709:2380018-2380416 [Yersinia pseudotuberculosis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT114095 NZ_CP033709:2380018-2380416 [Yersinia pseudotuberculosis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Antitoxin

• AlphaFold DB: Q666X1