Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1323771..1324426 Replicon chromosome
Accession NZ_CP033334
Organism Mesorhizobium loti strain NZP2042

Toxin (Protein)


Gene name vapC Uniprot ID A0A6M7VJD6
Locus tag EB815_RS06385 Protein ID WP_065005498.1
Coordinates 1323771..1324172 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0Q8KJP8
Locus tag EB815_RS06390 Protein ID WP_056575098.1
Coordinates 1324172..1324426 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB815_RS06365 1319206..1320240 - 1035 WP_056575085.1 aldo/keto reductase -
EB815_RS06370 1320296..1321477 - 1182 WP_065005497.1 MFS transporter -
EB815_RS06375 1321617..1322525 + 909 WP_056575089.1 LysR family transcriptional regulator -
EB815_RS06380 1322573..1323622 - 1050 WP_056575092.1 aldo/keto reductase -
EB815_RS06385 1323771..1324172 - 402 WP_065005498.1 type II toxin-antitoxin system VapC family toxin Toxin
EB815_RS06390 1324172..1324426 - 255 WP_056575098.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EB815_RS06395 1324507..1325169 - 663 WP_056575101.1 YggS family pyridoxal phosphate-dependent enzyme -
EB815_RS06400 1325326..1327950 + 2625 WP_065005499.1 leucine--tRNA ligase -
EB815_RS06405 1327937..1328515 + 579 WP_056575107.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14941.09 Da        Isoelectric Point: 5.2325

>T113517 WP_065005498.1 NZ_CP033334:c1324172-1323771 [Mesorhizobium loti]
MYLLDTNIVSDVQRRLPKPTEWLASVDPTSVSLSVITLGEIERGIIKLRKVDSEKATRLDLWLRELRRDNADRILAVTED
VALTWGRITARRTRGSADTLIAATALVHDLILVTRNVADFDDTGVTVFNPWDA

Download         Length: 402 bp

>T113517 NZ_CP033334:c1324172-1323771 [Mesorhizobium loti]
ATGTATCTGCTCGACACGAACATCGTTTCGGATGTGCAGAGGCGACTACCCAAGCCAACCGAATGGCTGGCTTCGGTGGA
TCCGACCTCGGTCAGCCTCAGCGTCATCACGCTTGGAGAGATCGAACGTGGGATCATCAAGCTACGCAAGGTCGACTCCG
AAAAGGCAACACGCCTCGATCTGTGGCTACGGGAGCTTCGGCGCGACAATGCCGATCGTATTCTCGCCGTCACGGAAGAT
GTCGCGTTAACTTGGGGCCGCATCACCGCCCGCCGTACACGAGGCAGCGCCGATACCCTCATCGCGGCTACCGCTCTTGT
CCATGATCTCATTCTTGTGACGCGCAATGTTGCCGACTTCGACGATACAGGCGTGACGGTGTTCAATCCCTGGGACGCCT
AA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9581.72 Da        Isoelectric Point: 5.1409

>AT113517 WP_056575098.1 NZ_CP033334:c1324426-1324172 [Mesorhizobium loti]
MNWHLQDAKNNFSKVVQRARSEGPQTVTLRGERAAVVLSAEDYDRLAGKKKSLAEYLLTGPVWDDDFAEEVSRRSETMIR
DVDL

Download         Length: 255 bp

>AT113517 NZ_CP033334:c1324426-1324172 [Mesorhizobium loti]
ATGAACTGGCACCTTCAGGACGCAAAGAACAATTTCTCCAAGGTGGTTCAGCGTGCGCGCAGCGAGGGACCGCAGACGGT
GACGTTGCGCGGCGAGCGCGCCGCAGTGGTGCTTTCCGCCGAGGATTACGACCGCCTGGCCGGAAAGAAGAAGTCGTTGG
CCGAATATCTTTTGACTGGTCCGGTTTGGGACGATGATTTCGCCGAAGAGGTCAGCCGCCGCTCGGAGACGATGATCCGG
GACGTCGATCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M7VJD6

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q8KJP8

References