Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 532015..532603 Replicon chromosome
Accession NZ_CP032905
Organism Helicobacter pylori strain 26-A-EK1

Toxin (Protein)


Gene name TfiT Uniprot ID T5CGR9
Locus tag D4J22_RS02735 Protein ID WP_000921933.1
Coordinates 532015..532296 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID A0A0B2EBX0
Locus tag D4J22_RS02740 Protein ID WP_042636159.1
Coordinates 532289..532603 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4J22_RS02710 527104..529131 - 2028 WP_139547022.1 RNA degradosome polyphosphate kinase -
D4J22_RS02725 530246..530950 + 705 Protein_514 integrase -
D4J22_RS02730 531219..531740 + 522 Protein_515 type IV secretory system conjugative DNA transfer family protein -
D4J22_RS02735 532015..532296 - 282 WP_000921933.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D4J22_RS02740 532289..532603 - 315 WP_042636159.1 hypothetical protein Antitoxin
D4J22_RS02745 532943..534856 + 1914 WP_139547023.1 relaxase/mobilization nuclease domain-containing protein -
D4J22_RS02750 534876..536054 - 1179 WP_139547024.1 hypothetical protein -
D4J22_RS02755 536098..536382 - 285 WP_000394655.1 hypothetical protein -
D4J22_RS02760 536465..537121 - 657 WP_139547025.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 530306..596873 66567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10875.80 Da        Isoelectric Point: 9.5726

>T112820 WP_000921933.1 NZ_CP032905:c532296-532015 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T112820 NZ_CP032905:c532296-532015 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTGCAAGCATTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGTAATC
TTAAAGGGTTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGTGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12296.75 Da        Isoelectric Point: 5.6761

>AT112820 WP_042636159.1 NZ_CP032905:c532603-532289 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAERDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT112820 NZ_CP032905:c532603-532289 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAAGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTCTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T5CGR9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B2EBX0

References