Detailed information of TA system TA112592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2028569..2029098
• Replicon: chromosome
• Accession: NZ_CP032821
• Organism: Staphylococcus aureus strain JDFM SA01

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX2
• Locus tag: D5S13_RS10000
• Protein ID: WP_001103933.1
• Coordinates: 2028781..2029098 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A6B0BJC0
• Locus tag: D5S13_RS09995
• Protein ID: WP_001058487.1
• Coordinates: 2028569..2028778 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5S13_RS09960 (D5S13_01906)	2023800..2024084	+	285	WP_000917289.1	co-chaperone GroES	-
D5S13_RS09965 (D5S13_01907)	2024160..2025776	+	1617	WP_000240642.1	chaperonin GroEL	-
D5S13_RS09970 (D5S13_01908)	2025845..2027017	-	1173	WP_000179353.1	tyrosine-type recombinase/integrase	-
D5S13_RS09975 (D5S13_01909)	2027031..2027753	-	723	WP_000672427.1	helix-turn-helix transcriptional regulator	-
D5S13_RS09980 (D5S13_01910)	2027906..2028112	+	207	WP_000794657.1	helix-turn-helix transcriptional regulator	-
D5S13_RS09985 (D5S13_01911)	2028116..2028433	+	318	WP_000481968.1	helix-turn-helix domain-containing protein	-
D5S13_RS09990 (D5S13_01912)	2028430..2028576	+	147	WP_000708434.1	hypothetical protein	-
D5S13_RS09995 (D5S13_01913)	2028569..2028778	+	210	WP_001058487.1	hypothetical protein	Antitoxin
D5S13_RS10000 (D5S13_01914)	2028781..2029098	+	318	WP_001103933.1	DUF1474 family protein	Toxin
D5S13_RS10005 (D5S13_01915)	2029165..2030034	+	870	WP_001002699.1	primase alpha helix C-terminal domain-containing protein	-
D5S13_RS10010 (D5S13_01916)	2030051..2031520	+	1470	WP_001838755.1	virulence-associated E family protein	-
D5S13_RS10015 (D5S13_01917)	2031806..2032168	+	363	WP_001039169.1	hypothetical protein	-
D5S13_RS10020 (D5S13_01918)	2032170..2032454	+	285	WP_000998179.1	hypothetical protein	-
D5S13_RS10025 (D5S13_01919)	2032451..2033092	+	642	WP_001019811.1	hypothetical protein	-
D5S13_RS10030 (D5S13_01920)	2033628..2033969	+	342	WP_001190614.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / map	2023800..2099262	75462

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12511.13 Da
• Isoelectric Point: 4.6364

>T112592 WP_001103933.1 NZ_CP032821:2028781-2029098 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Nucleotide

• Length: 318 bp

>T112592 NZ_CP032821:2028781-2029098 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8228.24 Da
• Isoelectric Point: 4.1682

>AT112592 WP_001058487.1 NZ_CP032821:2028569-2028778 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT112592 NZ_CP032821:2028569-2028778 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: K7ZRX2

Antitoxin

• AlphaFold DB: A0A6B0BJC0