Detailed information of TA system TA112457

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3620757..3620982
• Replicon: chromosome
• Accession: NZ_CP032803
• Organism: Escherichia coli strain ERL05-1306

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: D8Z70_RS19230
• Protein ID: WP_000813263.1
• Coordinates: 3620757..3620912 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3620924..3620982 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8Z70_RS19195	3616211..3616924	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
D8Z70_RS19200	3617062..3617258	-	197	Protein_3637	TrmB family transcriptional regulator	-
D8Z70_RS19205	3617545..3618363	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
D8Z70_RS19210	3618515..3618886	-	372	WP_000090264.1	antitermination protein	-
D8Z70_RS19215	3618876..3619247	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
D8Z70_RS19220	3619260..3620309	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
D8Z70_RS19225	3620311..3620589	-	279	WP_001341388.1	hypothetical protein	-
D8Z70_RS19230	3620757..3620912	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3620924..3620982	+	59	-	-	Antitoxin
D8Z70_RS19240	3621517..3622290	+	774	WP_000160654.1	alpha/beta hydrolase	-
D8Z70_RS19245	3622642..3623055	-	414	WP_001151233.1	DUF977 family protein	-
D8Z70_RS19250	3623071..3623841	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
D8Z70_RS19255	3623863..3624609	-	747	WP_000788751.1	ATP-binding protein	-
D8Z70_RS19260	3624616..3625707	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T112457 WP_000813263.1 NZ_CP032803:c3620912-3620757 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T112457 NZ_CP032803:c3620912-3620757 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT112457 NZ_CP032803:3620924-3620982 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin