Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 49366..50021 | Replicon | plasmid pN45955_1 |
| Accession | NZ_CP032388 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain CVM N45955 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | M7RF18 |
| Locus tag | D5F98_RS25085 | Protein ID | WP_000812999.1 |
| Coordinates | 49366..49794 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | H9AC95 |
| Locus tag | D5F98_RS25090 | Protein ID | WP_001261283.1 |
| Coordinates | 49791..50021 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D5F98_RS25040 | 44767..45531 | + | 765 | WP_000827659.1 | K88 minor fimbrial subunit faeI | - |
| D5F98_RS25045 | 45518..45793 | + | 276 | WP_001020576.1 | hypothetical protein | - |
| D5F98_RS25050 | 45793..46506 | + | 714 | WP_000801115.1 | hypothetical protein | - |
| D5F98_RS25060 | 46631..47215 | + | 585 | WP_001575501.1 | hypothetical protein | - |
| D5F98_RS25065 | 47288..47500 | + | 213 | WP_000063794.1 | hypothetical protein | - |
| D5F98_RS26010 | 47761..47922 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| D5F98_RS25070 | 47948..48796 | + | 849 | WP_000175391.1 | SdiA-regulated domain-containing protein | - |
| D5F98_RS25085 | 49366..49794 | - | 429 | WP_000812999.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| D5F98_RS25090 | 49791..50021 | - | 231 | WP_001261283.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| D5F98_RS25095 | 50766..50984 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| D5F98_RS25100 | 50986..51291 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | - |
| D5F98_RS25105 | 51293..51583 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| D5F98_RS25110 | 51580..52101 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| D5F98_RS25115 | 52136..52918 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| D5F98_RS25120 | 52927..53639 | + | 713 | Protein_64 | EAL domain-containing protein | - |
| D5F98_RS25125 | 53643..54152 | + | 510 | WP_001541544.1 | CaiF/GrlA family transcriptional regulator | - |
| D5F98_RS25130 | 54146..54482 | + | 337 | Protein_66 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..124532 | 124532 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 21064.27 Da Isoelectric Point: 5.5500
>T111722 WP_000812999.1 NZ_CP032388:c49794-49366 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 429 bp
>T111722 NZ_CP032388:c49794-49366 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin
Download Length: 77 a.a. Molecular weight: 11350.61 Da Isoelectric Point: 5.5500
>AT111722 WP_001261283.1 NZ_CP032388:c50021-49791 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Download Length: 231 bp
>AT111722 NZ_CP032388:c50021-49791 [Salmonella enterica subsp. enterica serovar Dublin]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | M7RF18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6X6R7C5 |