Detailed information of TA system TA111702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1154949..1155465
• Replicon: chromosome
• Accession: NZ_CP032358
• Organism: Pseudomonas protegens strain pf5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F9XXF1
• Locus tag: D3X12_RS05370
• Protein ID: WP_011058535.1
• Coordinates: 1155184..1155465 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4KKD3
• Locus tag: D3X12_RS05365
• Protein ID: WP_011058534.1
• Coordinates: 1154949..1155194 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3X12_RS05350	1152443..1154053	+	1611	WP_011058531.1	glycosyltransferase family 39 protein	-
D3X12_RS05355	1154163..1154624	+	462	WP_011058532.1	YbaK/EbsC family protein	-
D3X12_RS05360	1154639..1154884	+	246	WP_011058533.1	DUF2789 domain-containing protein	-
D3X12_RS05365	1154949..1155194	+	246	WP_011058534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D3X12_RS05370	1155184..1155465	+	282	WP_011058535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D3X12_RS05375	1155608..1156036	+	429	WP_011058536.1	winged helix DNA-binding protein	-
D3X12_RS05380	1156033..1158120	+	2088	WP_011058537.1	FUSC family protein	-
D3X12_RS05385	1158117..1158326	+	210	WP_011058538.1	DUF1656 domain-containing protein	-
D3X12_RS05390	1158323..1159213	+	891	WP_011058539.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10839.72 Da
• Isoelectric Point: 10.2298

>T111702 WP_011058535.1 NZ_CP032358:1155184-1155465 [Pseudomonas protegens]
MTYSLEFLPSAHKEWNKLGHTLREQFKKKLAERLEVPRIPADALHGLPDCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGTVYEQARKR

Nucleotide

• Length: 282 bp

>T111702 NZ_CP032358:1155184-1155465 [Pseudomonas protegens]
ATGACTTATAGCCTTGAGTTCCTGCCTTCGGCACACAAGGAATGGAACAAGTTGGGGCATACGCTTCGAGAGCAATTCAA
GAAAAAGCTCGCCGAACGGCTTGAGGTGCCGCGAATCCCTGCTGATGCCCTGCATGGGCTTCCCGATTGCTACAAAATTA
AACTCAAGGCTTCGGGCTACCGATTGGTTTATCAAGTGATCGAAGAGCGCGTCGTGGTTTGCGTGGTTGCGGTCGGCAAG
CGCGAGCGTGGAACCGTTTACGAGCAGGCCAGGAAACGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8799.10 Da
• Isoelectric Point: 4.3988

>AT111702 WP_011058534.1 NZ_CP032358:1154949-1155194 [Pseudomonas protegens]
MQSILADKAVSVSELKKNPSAVLSGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIIRERSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT111702 NZ_CP032358:1154949-1155194 [Pseudomonas protegens]
ATGCAGAGTATTCTGGCTGACAAAGCCGTCAGCGTATCTGAGTTGAAGAAAAACCCTTCTGCCGTCTTGAGTGGTGCCCA
GGGCGGGCCAGTGGCGGTGTTGAATCACAATCGTGTCATGGGCTACATGGTTCCGGCCGAGGTTTTCGAAGCGTTGATGG
AACGCCTGGATGATCTGGAGTTGGCCGAAATCATCCGCGAGCGCAGCCATGAGACGCCCGTTCCGGTCAGTCTGGATGAC
TTATAG

Structures

Toxin

• AlphaFold DB: F9XXF1

Antitoxin

• AlphaFold DB: Q4KKD3