Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3419903..3420735 Replicon chromosome
Accession NZ_CP032145
Organism Escherichia coli strain 15.TR.026_OXA

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag D3F09_RS16745 Protein ID WP_001094454.1
Coordinates 3420361..3420735 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag D3F09_RS16740 Protein ID WP_001320394.1
Coordinates 3419903..3420271 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D3F09_RS16700 3416190..3416645 + 456 WP_000581493.1 hypothetical protein -
D3F09_RS16705 3416724..3416957 + 234 WP_001119719.1 DUF905 family protein -
D3F09_RS16715 3417057..3417875 + 819 WP_001234642.1 DUF945 domain-containing protein -
D3F09_RS16720 3417930..3418415 + 486 WP_029701480.1 antirestriction protein -
D3F09_RS16725 3418431..3418907 + 477 WP_001347688.1 RadC family protein -
D3F09_RS16730 3418970..3419191 + 222 WP_000692300.1 DUF987 domain-containing protein -
D3F09_RS16735 3419210..3419853 + 644 Protein_3216 antitoxin of toxin-antitoxin stability system -
D3F09_RS16740 3419903..3420271 + 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D3F09_RS16745 3420361..3420735 + 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
D3F09_RS16750 3420732..3421220 + 489 WP_000777545.1 hypothetical protein -
D3F09_RS16755 3421232..3421429 + 198 WP_000839276.1 DUF957 domain-containing protein -
D3F09_RS16760 3421526..3422095 + 570 WP_001290250.1 DUF4942 domain-containing protein -
D3F09_RS16765 3422438..3422608 + 171 Protein_3222 IS110 family transposase -
D3F09_RS16770 3423419..3424402 + 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
D3F09_RS16775 3424474..3425622 + 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T111154 WP_001094454.1 NZ_CP032145:3420361-3420735 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T111154 NZ_CP032145:3420361-3420735 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT111154 WP_001320394.1 NZ_CP032145:3419903-3420271 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT111154 NZ_CP032145:3419903-3420271 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References