Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4023972..4024230 Replicon chromosome
Accession NZ_CP032085
Organism Escherichia coli strain ATCC 25922

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag D1792_RS19325 Protein ID WP_000809168.1
Coordinates 4023972..4024124 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4024173..4024230 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1792_RS19305 4019217..4019930 - 714 WP_001102391.1 acidic protein MsyB -
D1792_RS19310 4019956..4020360 - 405 WP_000843687.1 DUF2541 family protein -
D1792_RS19315 4020732..4022648 + 1917 WP_000516135.1 molecular chaperone DnaK -
D1792_RS19320 4022737..4023867 + 1131 WP_001118465.1 molecular chaperone DnaJ -
D1792_RS19325 4023972..4024124 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 4024173..4024230 + 58 - - Antitoxin
D1792_RS19330 4024739..4025500 + 762 WP_001274832.1 hypothetical protein -
D1792_RS19335 4025520..4027013 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
D1792_RS19340 4027142..4028401 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T111085 WP_000809168.1 NZ_CP032085:c4024124-4023972 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T111085 NZ_CP032085:c4024124-4023972 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT111085 NZ_CP032085:4024173-4024230 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References