Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 149007..150757 Replicon chromosome
Accession NZ_CP032011
Organism Burkholderia cepacia strain 39628

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag C7S14_RS23415 Protein ID WP_192389531.1
Coordinates 149861..150757 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A365QHE5
Locus tag C7S14_RS23410 Protein ID WP_059497041.1
Coordinates 149007..149864 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7S14_RS23390 144171..145661 - 1491 WP_059484807.1 aldehyde dehydrogenase -
C7S14_RS23395 145734..146561 - 828 WP_059622588.1 aspartate dehydrogenase -
C7S14_RS23400 146554..148194 - 1641 WP_192390232.1 thiamine pyrophosphate-binding protein -
C7S14_RS23405 148213..149010 - 798 WP_192389529.1 SDR family oxidoreductase -
C7S14_RS23410 149007..149864 - 858 WP_059497041.1 IclR family transcriptional regulator Antitoxin
C7S14_RS23415 149861..150757 - 897 WP_192389531.1 alpha/beta fold hydrolase Toxin
C7S14_RS23420 150776..151303 - 528 WP_021161513.1 cupin domain-containing protein -
C7S14_RS23425 151336..152106 - 771 WP_192389533.1 SDR family oxidoreductase -
C7S14_RS23430 152099..153169 - 1071 WP_021161515.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
C7S14_RS23435 153246..153557 - 312 WP_021161516.1 hypothetical protein -
C7S14_RS23440 153561..153878 - 318 WP_021161517.1 non-heme iron oxygenase ferredoxin subunit -
C7S14_RS23445 153973..154299 - 327 WP_192389535.1 hypothetical protein -
C7S14_RS23450 154324..155403 + 1080 WP_176130833.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30531.67 Da        Isoelectric Point: 7.7326

>T110924 WP_192389531.1 NZ_CP032011:c150757-149861 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHGGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRQCDQQRGPA

Download         Length: 897 bp

>T110924 NZ_CP032011:c150757-149861 [Burkholderia cepacia]
ATGAGTGTCATCGACAAACGCGAGCGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTACCGTGAGGCCGGCGCGCAGCATGGGGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCAGCCAGCTCGACACGCTCGGCGCATCGCGACGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGTGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTATGGCAGCGCACCGGCCGAAACACGC
GAATCGCGCCGCGATGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAACAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGACGCACGTGCGTGGGTGCGCTGGAACATGGCGCGTATCGTGCCGGCCGGCTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGTCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCTGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGTCATGCCGGTTATGTCGAGGCGCCGGCCGTCTATTCCGCGCTGATCGACTCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCCGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31546.09 Da        Isoelectric Point: 6.6572

>AT110924 WP_059497041.1 NZ_CP032011:c149864-149007 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRSLYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT110924 NZ_CP032011:c149864-149007 [Burkholderia cepacia]
ATGAACGAACCGCTGCAACGACCCGAACCCGAAAACGACAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGTGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGTGATGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTCAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGCTCGTTGTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAAATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTATGAAAGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A365QHE5

References