Detailed information of TA system TA110922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1313753..1314426
• Replicon: chromosome
• Accession: NZ_CP032009
• Organism: Burkholderia cepacia strain 39628

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: U2G353
• Locus tag: C7S14_RS05975
• Protein ID: WP_021160096.1
• Coordinates: 1314010..1314426 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: U2FLJ7
• Locus tag: C7S14_RS05970
• Protein ID: WP_021160097.1
• Coordinates: 1313753..1314013 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7S14_RS05955	1309332..1311560	+	2229	WP_192387335.1	TonB-dependent siderophore receptor	-
C7S14_RS05960	1311647..1312486	+	840	WP_060276653.1	N(5)-hydroxyornithine transformylase PvdF	-
C7S14_RS05965	1312486..1313502	+	1017	WP_192387337.1	acetyltransferase	-
C7S14_RS05970	1313753..1314013	+	261	WP_021160097.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C7S14_RS05975	1314010..1314426	+	417	WP_021160096.1	PIN domain-containing protein	Toxin
C7S14_RS05980	1314475..1315380	-	906	WP_059496029.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
C7S14_RS05985	1315349..1316422	-	1074	WP_060069922.1	hypothetical protein	-
C7S14_RS05990	1316763..1317926	+	1164	WP_192387339.1	amidohydrolase	-
C7S14_RS05995	1318170..1318709	+	540	WP_042975462.1	outer membrane protein assembly factor BamE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14566.75 Da
• Isoelectric Point: 7.8895

>T110922 WP_021160096.1 NZ_CP032009:1314010-1314426 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Nucleotide

• Length: 417 bp

>T110922 NZ_CP032009:1314010-1314426 [Burkholderia cepacia]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GGAAGGCTTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGGGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGCGATTCGCGCCGATCTCGCCGCGCGCGGCATGCCGATCGGCGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGTGCGGTGCTCGTCACGAACAACGGGCGGGAGTTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGACTGGGCAGCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9546.80 Da
• Isoelectric Point: 4.6151

>AT110922 WP_021160097.1 NZ_CP032009:1313753-1314013 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Nucleotide

• Length: 261 bp

>AT110922 NZ_CP032009:1313753-1314013 [Burkholderia cepacia]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGTCGCGAGGGCGACACGCTGCTGCTGCGGCCCGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Structures

Toxin

• AlphaFold DB: U2G353

Antitoxin

• AlphaFold DB: U2FLJ7