Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3790584..3791204 Replicon chromosome
Accession NZ_CP031726
Organism Enterobacter hormaechei strain WCHEH020038

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag D0Z05_RS21590 Protein ID WP_015571250.1
Coordinates 3790584..3790802 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag D0Z05_RS21595 Protein ID WP_006809850.1
Coordinates 3790830..3791204 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z05_RS21560 3786596..3786856 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
D0Z05_RS21565 3786859..3786999 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
D0Z05_RS21570 3786996..3787706 - 711 WP_022650493.1 GNAT family N-acetyltransferase -
D0Z05_RS21575 3787808..3789268 + 1461 WP_058652690.1 PLP-dependent aminotransferase family protein -
D0Z05_RS21580 3789240..3789707 - 468 WP_022650495.1 hypothetical protein -
D0Z05_RS21585 3789824..3790375 - 552 WP_022650496.1 maltose O-acetyltransferase -
D0Z05_RS21590 3790584..3790802 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
D0Z05_RS21595 3790830..3791204 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
D0Z05_RS21600 3791715..3794861 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
D0Z05_RS21605 3794884..3796077 - 1194 WP_058652691.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T109976 WP_015571250.1 NZ_CP031726:c3790802-3790584 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T109976 NZ_CP031726:c3790802-3790584 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTCTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT109976 WP_006809850.1 NZ_CP031726:c3791204-3790830 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT109976 NZ_CP031726:c3791204-3790830 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGCCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References