Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 238545..239071 Replicon plasmid pCTXM9_020038
Accession NZ_CP031724
Organism Enterobacter hormaechei strain WCHEH020038

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag D0Z05_RS02565 Protein ID WP_000323025.1
Coordinates 238545..238832 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag D0Z05_RS02570 Protein ID WP_000534858.1
Coordinates 238832..239071 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0Z05_RS25560 234115..234291 - 177 WP_001371930.1 hypothetical protein -
D0Z05_RS02535 234802..235746 + 945 WP_000778029.1 DUF5417 domain-containing protein -
D0Z05_RS02540 235845..236444 + 600 WP_001031420.1 hypothetical protein -
D0Z05_RS02545 236504..236854 + 351 WP_000743059.1 hypothetical protein -
D0Z05_RS02550 236901..237104 + 204 WP_001015183.1 hypothetical protein -
D0Z05_RS02555 237386..237706 + 321 WP_000332796.1 hypothetical protein -
D0Z05_RS02560 238315..238473 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
D0Z05_RS02565 238545..238832 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
D0Z05_RS02570 238832..239071 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
D0Z05_RS02580 239334..240257 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
D0Z05_RS02585 240457..241029 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
D0Z05_RS02590 241505..242743 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aadA2 / qacE / sul1 / qnrA1 / tet(A) / blaSHV-12 / catA1 / dfrA16 / blaCTX-M-9 / mcr-9 - 1..296580 296580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T109963 WP_000323025.1 NZ_CP031724:c238832-238545 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T109963 NZ_CP031724:c238832-238545 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT109963 WP_000534858.1 NZ_CP031724:c239071-238832 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT109963 NZ_CP031724:c239071-238832 [Enterobacter hormaechei]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References