Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 305439..306043 Replicon chromosome
Accession NZ_CP031684
Organism Haemophilus influenzae strain P652-8881

Toxin (Protein)


Gene name relE Uniprot ID A0A112W1Q1
Locus tag CH613_RS01570 Protein ID WP_005661261.1
Coordinates 305439..305747 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Y7JSS2
Locus tag CH613_RS01575 Protein ID WP_005661259.1
Coordinates 305747..306043 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH613_RS08960 302049..302330 + 282 WP_205415524.1 PT domain-containing protein -
CH613_RS01565 302369..305383 + 3015 WP_116946752.1 TonB-dependent receptor -
CH613_RS01570 305439..305747 - 309 WP_005661261.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
CH613_RS01575 305747..306043 - 297 WP_005661259.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CH613_RS01580 306163..307017 - 855 WP_005687862.1 DUF3298 domain-containing protein -
CH613_RS01585 307036..308895 - 1860 WP_012054618.1 selenocysteine-specific translation elongation factor -
CH613_RS01590 308892..310277 - 1386 WP_012054619.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11895.63 Da        Isoelectric Point: 7.3189

>T109803 WP_005661261.1 NZ_CP031684:c305747-305439 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T109803 NZ_CP031684:c305747-305439 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.37 Da        Isoelectric Point: 4.4297

>AT109803 WP_005661259.1 NZ_CP031684:c306043-305747 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT109803 NZ_CP031684:c306043-305747 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112W1Q1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Y7JSS2

References