Detailed information of TA system TA109722

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1636679..1637258
• Replicon: chromosome
• Accession: NZ_CP031670
• Organism: Staphylococcus aureus strain 64

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DD547_RS08460
• Protein ID: WP_001025401.1
• Coordinates: 1637013..1637258 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1636679..1637044 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD547_RS08420	1633421..1633978	-	558	WP_000645045.1	DUF2815 family protein	-
DD547_RS08425	1634004..1635170	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
DD547_RS08430	1635167..1635529	-	363	WP_000985986.1	hypothetical protein	-
DD547_RS08435	1635544..1635867	-	324	WP_000175000.1	hypothetical protein	-
DD547_RS08440	1635947..1636108	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
DD547_RS08445	1636121..1636384	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
DD547_RS08450	1636409..1636624	-	216	WP_001097552.1	hypothetical protein	-
DD547_RS08455	1636679..1637044	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DD547_RS08460	1637013..1637258	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DD547_RS08465	1637308..1637526	-	219	WP_001001383.1	hypothetical protein	-
DD547_RS08470	1637542..1638318	-	777	WP_001148559.1	phage antirepressor	-
DD547_RS08475	1638344..1638571	-	228	WP_001030311.1	hypothetical protein	-
DD547_RS08480	1638743..1639357	+	615	WP_000801423.1	XRE family transcriptional regulator	-
DD547_RS08485	1639373..1640293	+	921	WP_031903415.1	3'-5' exoribonuclease	-
DD547_RS08490	1640389..1640571	+	183	WP_000705240.1	hypothetical protein	-
DD547_RS08495	1640607..1640753	+	147	WP_001013104.1	hypothetical protein	-
DD547_RS08500	1640750..1641364	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1594154..1660326	66172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T109722 WP_001025401.1 NZ_CP031670:c1637258-1637013 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T109722 NZ_CP031670:c1637258-1637013 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCTGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT109722 NZ_CP031670:1636679-1637044 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin