Detailed information of TA system TA109340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2411515..2412047
• Replicon: chromosome
• Accession: NZ_CP031537
• Organism: Staphylococcus aureus strain WCH-SK2

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: LR49_RS12620
• Protein ID: WP_001103942.1
• Coordinates: 2411727..2412047 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: LR49_RS12615
• Protein ID: WP_116100508.1
• Coordinates: 2411515..2411724 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LR49_RS12580	2407845..2408309	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
LR49_RS12590	2408872..2409978	-	1107	WP_106699245.1	site-specific integrase	-
LR49_RS12595	2409968..2410771	-	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
LR49_RS12600	2410907..2411110	+	204	WP_001045296.1	transcriptional regulator	-
LR49_RS12605	2411146..2411364	+	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
LR49_RS12610	2411376..2411522	+	147	WP_000784885.1	hypothetical protein	-
LR49_RS12615	2411515..2411724	+	210	WP_116100508.1	pathogenicity island protein	Antitoxin
LR49_RS12620	2411727..2412047	+	321	WP_001103942.1	DUF1474 family protein	Toxin
LR49_RS12625	2412111..2412980	+	870	WP_053040303.1	primase alpha helix C-terminal domain-containing protein	-
LR49_RS12630	2412997..2414466	+	1470	WP_053040304.1	virulence-associated E family protein	-
LR49_RS12635	2414745..2415107	+	363	WP_001039165.1	hypothetical protein	-
LR49_RS12640	2415109..2415372	+	264	WP_001804819.1	hypothetical protein	-
LR49_RS12645	2415374..2416015	+	642	WP_116100509.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T109340 WP_001103942.1 NZ_CP031537:2411727-2412047 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T109340 NZ_CP031537:2411727-2412047 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8166.22 Da
• Isoelectric Point: 4.4665

>AT109340 WP_116100508.1 NZ_CP031537:2411515-2411724 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLGKGE

Nucleotide

• Length: 210 bp

>AT109340 NZ_CP031537:2411515-2411724 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTAGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGGGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4