Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 38738..39395 Replicon plasmid p3
Accession NZ_CP031362
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain 5

Toxin (Protein)


Gene name higB Uniprot ID U3PDC3
Locus tag DXF95_RS24095 Protein ID WP_000270043.1
Coordinates 39045..39395 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DXF95_RS24090 Protein ID WP_000124640.1
Coordinates 38738..39040 (-) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXF95_RS24040 34361..34789 + 429 WP_000591074.1 hypothetical protein -
DXF95_RS24045 34846..35205 + 360 WP_000422768.1 hypothetical protein -
DXF95_RS24050 35205..35651 + 447 WP_000919345.1 Fe3+-siderophore ABC transporter permease -
DXF95_RS24055 35648..36166 + 519 WP_020833600.1 hypothetical protein -
DXF95_RS24060 36166..36396 + 231 WP_020833601.1 hypothetical protein -
DXF95_RS24065 36383..37240 + 858 WP_052870225.1 hypothetical protein -
DXF95_RS24075 37471..37998 + 528 WP_020833604.1 thermonuclease family protein -
DXF95_RS24080 38056..38328 + 273 WP_020833605.1 HU family DNA-binding protein -
DXF95_RS24085 38417..38710 + 294 WP_020833606.1 chromosome segregation protein ParM -
DXF95_RS24090 38738..39040 - 303 WP_000124640.1 XRE family transcriptional regulator Antitoxin
DXF95_RS24095 39045..39395 - 351 WP_000270043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DXF95_RS24100 39558..40106 + 549 WP_001061574.1 transcriptional regulator -
DXF95_RS24110 40447..40641 + 195 WP_000343597.1 hypothetical protein -
DXF95_RS24115 40649..41020 + 372 WP_020833608.1 hypothetical protein -
DXF95_RS24120 41013..41483 + 471 WP_001281821.1 hypothetical protein -
DXF95_RS24125 41492..41848 - 357 WP_020833609.1 hypothetical protein -
DXF95_RS24130 41945..42433 + 489 WP_001273096.1 DUF1643 domain-containing protein -
DXF95_RS24135 42436..42933 + 498 WP_000062185.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..190543 190543


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-126)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 17237.68 Da        Isoelectric Point: 5.5500

>T109145 WP_000270043.1 NZ_CP031362:c39395-39045 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 351 bp

>T109145 NZ_CP031362:c39395-39045 [Salmonella enterica subsp. enterica serovar Heidelberg]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 14882.85 Da        Isoelectric Point: 5.5500

>AT109145 WP_000124640.1 NZ_CP031362:c39040-38738 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Download         Length: 303 bp

>AT109145 NZ_CP031362:c39040-38738 [Salmonella enterica subsp. enterica serovar Heidelberg]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7G8AFB9


Antitoxin

Source ID Structure

References